|
|
|
|
| LEADER |
01000caa a22002652c 4500 |
| 001 |
NLM225858983 |
| 003 |
DE-627 |
| 005 |
20250215034613.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231224s2013 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1016/j.clim.2013.02.006
|2 doi
|
| 028 |
5 |
2 |
|a pubmed25n0752.xml
|
| 035 |
|
|
|a (DE-627)NLM225858983
|
| 035 |
|
|
|a (NLM)23498776
|
| 035 |
|
|
|a (PII)S1521-6616(13)00041-7
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Correale, Jorge
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Sex-specific environmental influences affecting MS development
|
| 264 |
|
1 |
|c 2013
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 17.12.2013
|
| 500 |
|
|
|a Date Revised 21.10.2013
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Copyright © 2013 Elsevier Inc. All rights reserved.
|
| 520 |
|
|
|a Vitamin D status, smoking, and Epstein-Barr virus infection (EBV) may all contribute to explain differences in disease prevalence and incidence of Multiple Sclerosis (MS). MS affects women more often than men, and recent cross-sectional study assessments provide evidence of increased female to male prevalence in relapsing remitting MS patients, suggesting that sex hormones may exert an active role in disease pathogenesis. Studies in both humans and animal disease models demonstrate a functional synergy for the immunomodulatory effects of Vitamin D3 and 17-β estradiol. Both smoking and EBV infection clearly increase MS risk, and smoking history has also been associated with poorer disease prognosis. However, neither factor can explain the recent trend indicating greater female prevalence. Therefore, large population-based case-control studies from well defined geographic areas with homogeneous populations should be performed, in order to define environmental factor effects, and sex hormone influences, to better understand prevalence and incidence gender differences observed
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Environmental factors
|
| 650 |
|
4 |
|a Epstein–Barr virus
|
| 650 |
|
4 |
|a Gender
|
| 650 |
|
4 |
|a Multiple Sclerosis
|
| 650 |
|
4 |
|a Smoking
|
| 650 |
|
4 |
|a Vitamin D
|
| 650 |
|
7 |
|a Cholecalciferol
|2 NLM
|
| 650 |
|
7 |
|a 1C6V77QF41
|2 NLM
|
| 650 |
|
7 |
|a Estradiol
|2 NLM
|
| 650 |
|
7 |
|a 4TI98Z838E
|2 NLM
|
| 700 |
1 |
|
|a Balbuena Aguirre, María E
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Farez, Mauricio F
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 149(2013), 2 vom: 01. Nov., Seite 176-81
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
|
| 773 |
1 |
8 |
|g volume:149
|g year:2013
|g number:2
|g day:01
|g month:11
|g pages:176-81
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2013.02.006
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 149
|j 2013
|e 2
|b 01
|c 11
|h 176-81
|