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231224s2013 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2013.01.006
|2 doi
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2 |
|a pubmed24n0750.xml
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|a DE-627
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|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Heymann, Michael C
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Contribution of the inflammasomes to autoinflammatory diseases and recent mouse models as research tools
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| 264 |
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1 |
|c 2013
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 20.08.2013
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| 500 |
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|a Date Revised 25.11.2016
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2013 Elsevier Inc. All rights reserved.
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|a Inflammasomes are multiprotein complexes that serve as activating platforms for the enzyme caspase-1 in response to various danger signals. Active caspase-1 can cleave the precursors of the pro-inflammatory cytokines IL-1β and IL-18 and thereby activate them. Deregulation of this cascade caused by mutations in genes coding for inflammasomal components and their interaction partners can lead to severe disease. This review summarizes the contribution of deregulated inflammasomes to the field of autoinflammatory syndromes. In addition, it gives insight into currently available mouse models that are used to study and characterize the role of the inflammasome components in the pathophysiology of these diseases
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| 650 |
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|a Journal Article
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| 650 |
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|a Research Support, Non-U.S. Gov't
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|a Review
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| 650 |
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7 |
|a Carrier Proteins
|2 NLM
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| 650 |
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|a Cytoskeletal Proteins
|2 NLM
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| 650 |
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7 |
|a Inflammasomes
|2 NLM
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| 650 |
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7 |
|a Interleukin-18
|2 NLM
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| 650 |
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7 |
|a Interleukin-1beta
|2 NLM
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| 650 |
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7 |
|a NLR Family, Pyrin Domain-Containing 3 Protein
|2 NLM
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| 650 |
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7 |
|a Nlrp3 protein, mouse
|2 NLM
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| 650 |
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7 |
|a Pyrin
|2 NLM
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| 650 |
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7 |
|a Caspase 1
|2 NLM
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| 650 |
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7 |
|a EC 3.4.22.36
|2 NLM
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| 700 |
1 |
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|a Rösen-Wolff, Angela
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 147(2013), 3 vom: 26. Juni, Seite 175-84
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|x 1521-7035
|7 nnns
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| 773 |
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|g volume:147
|g year:2013
|g number:3
|g day:26
|g month:06
|g pages:175-84
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|u http://dx.doi.org/10.1016/j.clim.2013.01.006
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