|
|
|
|
| LEADER |
01000caa a22002652 4500 |
| 001 |
NLM224496409 |
| 003 |
DE-627 |
| 005 |
20250214222027.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231224s2013 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1016/j.clim.2012.12.009
|2 doi
|
| 028 |
5 |
2 |
|a pubmed25n0748.xml
|
| 035 |
|
|
|a (DE-627)NLM224496409
|
| 035 |
|
|
|a (NLM)23353785
|
| 035 |
|
|
|a (PII)S1521-6616(12)00309-9
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Luo, Shuangyan
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Aberrant histone modifications in peripheral blood mononuclear cells from patients with Henoch-Schönlein purpura
|
| 264 |
|
1 |
|c 2013
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 23.04.2013
|
| 500 |
|
|
|a Date Revised 09.04.2022
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Copyright © 2013 Elsevier Inc. All rights reserved.
|
| 520 |
|
|
|a Henoch-Schönlein purpura (HSP), the most common type of leukocytoclastic vasculitis, is caused by T cell-mediated autoimmune reactions. In this study, we analyze histone modification patterns in peripheral blood mononuclear cells (PBMCs) of HSP patients, and investigate the expression levels of inflammatory cytokines (IFN-γ, IL-2, IL-4, IL-6 and IL-13), transcription factors (T-bet, GATA-3 and TIM-1) and chemokines (CXCL4 and CXCL10) in HSP patients. Our results show that histone H3 acetylation and methylation are significantly enhanced in PBMCs from HSP patients. We also demonstrate specifically that marked increases in histone H3 acetylation and H3 lysine 4 trimethylation occur at the IL-4 loci in these patients. In addition, the expression levels of IL-4, IL-6, IL-13, GATA-3, TIM-1 and CXCL4 are also increased. These findings suggest that abnormal histone modifications are present in the PBMCs of patients with HSP, possibly contributing to the activation of pathological immune responses associated with HSP
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
7 |
|a Cytokines
|2 NLM
|
| 650 |
|
7 |
|a GATA3 Transcription Factor
|2 NLM
|
| 650 |
|
7 |
|a GATA3 protein, human
|2 NLM
|
| 650 |
|
7 |
|a HAVCR1 protein, human
|2 NLM
|
| 650 |
|
7 |
|a Hepatitis A Virus Cellular Receptor 1
|2 NLM
|
| 650 |
|
7 |
|a Histones
|2 NLM
|
| 650 |
|
7 |
|a Membrane Glycoproteins
|2 NLM
|
| 650 |
|
7 |
|a RNA, Messenger
|2 NLM
|
| 650 |
|
7 |
|a Receptors, Virus
|2 NLM
|
| 700 |
1 |
|
|a Liang, Gongping
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Zhang, Peng
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Zhao, Ming
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Lu, Qianjin
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 146(2013), 3 vom: 05. März, Seite 165-75
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
|
| 773 |
1 |
8 |
|g volume:146
|g year:2013
|g number:3
|g day:05
|g month:03
|g pages:165-75
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2012.12.009
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 146
|j 2013
|e 3
|b 05
|c 03
|h 165-75
|