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231224s2013 xx |||||o 00| ||eng c |
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|a 10.1021/la304534f
|2 doi
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|a pubmed24n0747.xml
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|a (DE-627)NLM224154788
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|a (NLM)23317411
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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1 |
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|a Escudero, Alberto
|e verfasserin
|4 aut
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|a Microwave-assisted synthesis of biocompatible europium-doped calcium hydroxyapatite and fluoroapatite luminescent nanospindles functionalized with poly(acrylic acid)
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|c 2013
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 29.07.2013
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|a Date Revised 10.12.2019
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Europium-doped calcium hydroxyapatite and fluoroapatite nanophosphors functionalized with poly(acrylic acid) (PAA) have been synthesized through a one-pot microwave-assisted hydrothermal method from aqueous basic solutions containing calcium nitrate, sodium phosphate monobasic, and PAA, as well as sodium fluoride in the case of the fluoroapatite particles. In both cases a spindlelike morphology was obtained, resulting from an aggregation process of smaller subunits which also gave rise to high specific surface area. The size of the nanospindles was 191 (32) × 40 (5) nm for calcium hydroxyapatite and 152 (24) × 38 (6) nm for calcium fluoroapatite. The luminescent nanoparticles showed the typical red luminescence of Eu(3+), which was more efficient for the fluoroapatite particles than for the hydroxyapatite. This is attributed to the presence of OH(-) quenchers in the latter. The nanophosphors showed negligible toxicity for Vero cells. Both PAA-functionalized nanophosphors showed a very high (up to at least 1 week) colloidal stability in 2-(N-morpholino)ethanesulfonic acid (MES) at pH 6.5, which is a commonly used buffer for physiological pH. All these features make both kinds of apatite-based nanoparticles promising tools for biomedical applications, such as luminescent biolabels and tracking devices in drug delivery systems
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Acrylic Resins
|2 NLM
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|a Apatites
|2 NLM
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|a Biocompatible Materials
|2 NLM
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|a Buffers
|2 NLM
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|a Luminescent Agents
|2 NLM
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|a Organometallic Compounds
|2 NLM
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|a Europium
|2 NLM
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|a 444W947O8O
|2 NLM
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|a carbopol 940
|2 NLM
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|a 4Q93RCW27E
|2 NLM
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| 650 |
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|a Durapatite
|2 NLM
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|a 91D9GV0Z28
|2 NLM
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| 650 |
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|a fluorapatite
|2 NLM
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| 650 |
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|a M4CM1H238J
|2 NLM
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| 700 |
1 |
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|a Calvo, Mauricio E
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rivera-Fernández, Sara
|e verfasserin
|4 aut
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| 700 |
1 |
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|a de la Fuente, Jesús M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ocaña, Manuel
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 29(2013), 6 vom: 12. Feb., Seite 1985-94
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:29
|g year:2013
|g number:6
|g day:12
|g month:02
|g pages:1985-94
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|u http://dx.doi.org/10.1021/la304534f
|3 Volltext
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|h 1985-94
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