Resistance to herbicides caused by single amino acid mutations in acetyl-CoA carboxylase in resistant populations of grassy weeds

Bibliographische Detailangaben
Veröffentlicht in:	The New phytologist. - 1979. - 197(2013), 4 vom: 14. März, Seite 1110-1116
1. Verfasser:	Jang, SoRi (VerfasserIn)
Weitere Verfasser:	Marjanovic, Jasmina, Gornicki, Piotr
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2013
Zugriff auf das übergeordnete Werk:	The New phytologist
Schlagworte:	Journal Article Herbicides Plant Proteins Acetyl-CoA Carboxylase EC 6.4.1.2

Beschreibung
Zusammenfassung:	© 2013 The Authors. New Phytologist © 2013 New Phytologist Trust. Eleven spontaneous mutations of acetyl-CoA carboxylase have been identified in many herbicide-resistant populations of 42 species of grassy weeds, hampering application of aryloxyphenoxypropionate, cyclohexadione and phenylpyrazoline herbicides in agriculture. IC(50) shifts (resistance indices) caused by herbicide-resistant mutations were determined using a recombinant yeast system that allows comparison of the effects of single amino acid mutations in the same biochemical background, avoiding the complexity inherent in the in planta experiments. The effect of six mutations on the sensitivity of acetyl-CoA carboxylase to nine herbicides representing the three chemical classes was studied. A combination of partially overlapping binding sites of the three classes of herbicides and the structure of their variable parts explains cross-resistance among and between the three classes of inhibitors, as well as differences in their specificity. Some degree of resistance was detected for 51 of 54 herbicide/mutation combinations. Introduction of new herbicides targeting acetyl-CoA carboxylase will depend on their ability to overcome the high degree of cross-resistance already existing in weed populations
Beschreibung:	Date Completed 19.07.2013 Date Revised 10.03.2022 published: Print-Electronic Citation Status MEDLINE
ISSN:	1469-8137
DOI:	10.1111/nph.12117