|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM223980714 |
| 003 |
DE-627 |
| 005 |
20231224061920.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231224s2013 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1002/mrc.3916
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n0746.xml
|
| 035 |
|
|
|a (DE-627)NLM223980714
|
| 035 |
|
|
|a (NLM)23296598
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Sippl, Stefanie P
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Conformational analysis of a secondary hydroxamic acid in aqueous solution by NOE spectroscopy
|
| 264 |
|
1 |
|c 2013
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 09.07.2013
|
| 500 |
|
|
|a Date Revised 16.01.2013
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status PubMed-not-MEDLINE
|
| 520 |
|
|
|a Copyright © 2013 John Wiley & Sons, Ltd.
|
| 520 |
|
|
|a Hydroxamic acids are metal-binding compounds used by micro-organisms and possess applications in medicine and industry. Hydroxamic acids favor two conformations, E and Z; metal binding is limited to the Z conformation. The Z conformation may be identifiable by NOE spectroscopy, but analysis is complicated by the potential for long-range coupling as well as for relayed NOEs due to conformational switching. In this report, we re-examine the reported conformational preference of N-methyl acetohydroxamic acid (NMHA) in D(2)O using NOE spectroscopy. We find that the favored conformation of NMHA in aqueous solution is the E conformation, contrary to an earlier report. NOE build-up curves are proposed as a valuable tool to probe conformational behavior in similar systems
|
| 650 |
|
4 |
|a Journal Article
|
| 700 |
1 |
|
|a Schenck, Heather L
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Magnetic resonance in chemistry : MRC
|d 1985
|g 51(2013), 2 vom: 21. Feb., Seite 72-5
|w (DE-627)NLM098179667
|x 1097-458X
|7 nnns
|
| 773 |
1 |
8 |
|g volume:51
|g year:2013
|g number:2
|g day:21
|g month:02
|g pages:72-5
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1002/mrc.3916
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 51
|j 2013
|e 2
|b 21
|c 02
|h 72-5
|