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231224s2013 xx |||||o 00| ||eng c |
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|a 10.1002/mrc.3916
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|a eng
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|a Sippl, Stefanie P
|e verfasserin
|4 aut
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|a Conformational analysis of a secondary hydroxamic acid in aqueous solution by NOE spectroscopy
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|c 2013
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 09.07.2013
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|a Date Revised 16.01.2013
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a Copyright © 2013 John Wiley & Sons, Ltd.
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|a Hydroxamic acids are metal-binding compounds used by micro-organisms and possess applications in medicine and industry. Hydroxamic acids favor two conformations, E and Z; metal binding is limited to the Z conformation. The Z conformation may be identifiable by NOE spectroscopy, but analysis is complicated by the potential for long-range coupling as well as for relayed NOEs due to conformational switching. In this report, we re-examine the reported conformational preference of N-methyl acetohydroxamic acid (NMHA) in D(2)O using NOE spectroscopy. We find that the favored conformation of NMHA in aqueous solution is the E conformation, contrary to an earlier report. NOE build-up curves are proposed as a valuable tool to probe conformational behavior in similar systems
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|a Journal Article
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|a Schenck, Heather L
|e verfasserin
|4 aut
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|i Enthalten in
|t Magnetic resonance in chemistry : MRC
|d 1985
|g 51(2013), 2 vom: 21. Feb., Seite 72-5
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|x 1097-458X
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|g volume:51
|g year:2013
|g number:2
|g day:21
|g month:02
|g pages:72-5
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|u http://dx.doi.org/10.1002/mrc.3916
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