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231224s2013 xx |||||o 00| ||eng c |
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|a 10.1107/S0909049512049114
|2 doi
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|a DE-627
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|a eng
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1 |
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|a Leal, Ricardo Miguel Ferraz
|e verfasserin
|4 aut
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| 245 |
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|a A survey of global radiation damage to 15 different protein crystal types at room temperature
|b a new decay model
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|c 2013
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 13.06.2013
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|a Date Revised 10.11.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The radiation damage rates to crystals of 15 model macromolecular structures were studied using an automated radiation sensitivity characterization procedure. The diffracted intensity variation with dose is described by a two-parameter model. This model includes a strong resolution-independent decay specific to room-temperature measurements along with a linear increase in overall Debye-Waller factors. An equivalent representation of sensitivity via a single parameter, normalized half-dose, is introduced. This parameter varies by an order of magnitude between the different structures studied. The data show a correlation of crystal radiation sensitivity with crystal solvent content but no dose-rate dependency was detected in the range 0.05-300 kGy s(-1). The results of the crystal characterization are suitable for either optimal planning of room-temperature data collection or in situ crystallization plate screening experiments
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|a Journal Article
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|a Proteins
|2 NLM
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| 650 |
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|a Solvents
|2 NLM
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| 700 |
1 |
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|a Bourenkov, Gleb
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Russi, Silvia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Popov, Alexander N
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Journal of synchrotron radiation
|d 1994
|g 20(2013), Pt 1 vom: 01. Jan., Seite 14-22
|w (DE-627)NLM09824129X
|x 1600-5775
|7 nnns
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| 773 |
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|g volume:20
|g year:2013
|g number:Pt 1
|g day:01
|g month:01
|g pages:14-22
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| 856 |
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|u http://dx.doi.org/10.1107/S0909049512049114
|3 Volltext
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|d 20
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|e Pt 1
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|h 14-22
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