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231224s2013 xx |||||o 00| ||eng c |
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|a 10.1021/la303634y
|2 doi
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|a pubmed24n0744.xml
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|a (DE-627)NLM223212032
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|a (NLM)23215353
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Zhang, Lidong
|e verfasserin
|4 aut
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|a Fabrication of microspheres via solvent volatization induced aggregation of self-assembled nanomicellar structures and their use as a pH-dependent drug release system
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|c 2013
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 14.06.2013
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|a Date Revised 21.11.2013
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a A series of oleamide derivatives, (C(18)H(34)NO)(2)(CH(2))(n) [n = 2 (1a), 3 (1b), 4 (1c), or 6 (1d); C(18)H(34)NO = oleic amide fragment] and (C(18)H(34)NO)(CH(2))(6)NH(2) (2), have been synthesized and their self-assembly is investigated in ethanol/water media. Self-assembly of 1a and 1b in ethanol/water (1/0.1 v/v) solution (5 mg mL(-1)) yields microspheres (MSs) with the average diameter ∼10 μm via a gradual temperature reduction and solvent volatilization process. Under the same self-assembly conditions, microrods (average diameter ∼6 μm and several tens of micrometers in length), micronecklace-like, and shape-irregular microparticles are formed from the self-assembly of 1c, 1d, and 2, respectively. The kinetics of evolution for their self-assemblies by dynamic light scattering technique and in situ observation by optical microscopy reveals that the microstructures formation is from a well-behaved aggregation of nanoscale micelles induced by solvent volatilization. The FT-IR and temperature-dependent (1)H-NMR spectra demonstrate the hydrogen bonding force and π-π stacking, which drove the self-assembly of all oleamide derivatives in ethanol/water. Among the fabricated microstructures, the MSs from 1a exhibit the best dispersity, which thus have been used as a scaffold for the in vitro release of doxorubicin. The results demonstrate a pH-sensitive release process, enhanced release specifically at low pH 5.2
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Micelles
|2 NLM
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|a Oleic Acids
|2 NLM
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|a Solvents
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|a Water
|2 NLM
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|a 059QF0KO0R
|2 NLM
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|a Ethanol
|2 NLM
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|a 3K9958V90M
|2 NLM
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|a oleylamide
|2 NLM
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|a 7L25QK8BWO
|2 NLM
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1 |
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|a Jeong, Young-Il
|e verfasserin
|4 aut
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|a Zheng, Sudan
|e verfasserin
|4 aut
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|a Suh, Hongsuk
|e verfasserin
|4 aut
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|a Kang, Dae Hwan
|e verfasserin
|4 aut
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|a Kim, Il
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 29(2013), 1 vom: 08. Jan., Seite 65-74
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:29
|g year:2013
|g number:1
|g day:08
|g month:01
|g pages:65-74
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|u http://dx.doi.org/10.1021/la303634y
|3 Volltext
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