Dissecting the carbohydrate specificity of the anti-HIV-1 2G12 antibody by single-molecule force spectroscopy

Broadly neutralizing anti-HIV-1 monoclonal antibody 2G12 exclusively targets a conserved cluster of high-mannose oligosaccharides present on outer viral envelope glycoprotein gp120. This characteristic makes the otherwise immunogenically "silent" glycan shield of gp120 a tempting target fo...

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Veröffentlicht in:	Langmuir : the ACS journal of surfaces and colloids. - 1992. - 28(2012), 51 vom: 21. Dez., Seite 17726-32
1. Verfasser:	Martines, Elena (VerfasserIn)
Weitere Verfasser:	García, Isabel, Marradi, Marco, Padro, Daniel, Penadés, Soledad
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2012
Zugriff auf das übergeordnete Werk:	Langmuir : the ACS journal of surfaces and colloids
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't 2G12 monoclonal antibody Antibodies, Monoclonal Broadly Neutralizing Antibodies HIV Antibodies HIV Envelope Protein gp120 gp120 protein, Human immunodeficiency virus 1 Mannose PHA4727WTP