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DE-627 |
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20250214160341.0 |
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231224s2012 xx ||||| 00| ||chi c |
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|a pubmed25n0742.xml
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|a (DE-627)NLM222776951
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|a (NLM)23168199
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Wang, Hong
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Evaluation of circulating microRNA-92a for endothelial damage induced by percutaneous coronary intervention
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1 |
|c 2012
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 16.12.2013
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|a Date Revised 21.11.2012
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a OBJECTIVE: To explore the role of microRNA-92a (miR-92a) in evaluating endothelium damage induced by percutaneous coronary intervention (PCI)
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|a METHODS: A case control study was prospectively conducted. Fifty-eight patients with ST-segment elevation acute myocardial infarction (STEAMI) received PCI were enrolled. MiR-92a expression in circulation was determined on the next day after PCI (reverse transcription-polymerase chain reaction). The correlation between miR-92a expression in circulation and PCI influence factors, such as inflation pressure, duration of balloon inflation and length of culprit atheromatous plaque were explored
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| 520 |
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|a RESULTS: MiR-92a was lower in inflation pressure 11-19 atm (1 atm=101.325 kPa) group [n=43, mean -0.36, 95% confidence interval (95%CI) -0.60 to -0.12] than inflation pressure ≤10 atm group (n=11, mean 1.16, 95%CI 0.80 to 1.52, P<0.01) and ≥ 20 atm group (n=4, mean 0.26, 95%CI 0.26 to 0.26, P=0.1); and also lower in duration of balloon inflation 6-7 seconds group (n=24, mean -0.42, 95%CI -0.83 to -0.01) than in duration of balloon inflation ≤ 5 seconds group (n=9, mean 0.63, 95%CI 0.49 to 0.78, P=0.03) and ≥ 8 seconds group (n=25, mean 0.45, 95%CI 0.10 to 0.80, P<0.001); lower in implanted stent length ≤30 mm (n=31, mean -0.48, 95%CI -0.80 to -0.16) than those >30 mm (n=27, mean 0.16, 95%CI 0.01 to 0.32, P<0.01). A significantly negative correlation was found between inflation pressure and duration of balloon inflation. (r=-0.48, P<0.001)
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|a CONCLUSIONS: There is a relationship between circulating miR-92a, inflation pressure and duration of balloon inflation. Circulating miR-92a could be used to evaluate the endothelium injury induced by PCI, and be used as a new target of prevention and treatment of endothelial dysfunction following revascularization
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|a English Abstract
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|a Journal Article
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|a Research Support, U.S. Gov't, Non-P.H.S.
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| 650 |
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7 |
|a MIRN92 microRNA, human
|2 NLM
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| 650 |
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7 |
|a MicroRNAs
|2 NLM
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| 700 |
1 |
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|a Wang, Lin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Ling
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lin, Ying-zhong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, You-qiong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lu, Hong-mei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gong, Guo-ping
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 24(2012), 12 vom: 14. Dez., Seite 721-4
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
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| 773 |
1 |
8 |
|g volume:24
|g year:2012
|g number:12
|g day:14
|g month:12
|g pages:721-4
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 24
|j 2012
|e 12
|b 14
|c 12
|h 721-4
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