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231224s2012 xx |||||o 00| ||eng c |
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|a 10.1080/08997659.2012.713890
|2 doi
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|a pubmed25n0741.xml
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|a (NLM)23134222
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Ottinger, Christopher A
|e verfasserin
|4 aut
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|a Impact of thiamine deficiency on T-cell dependent and T-cell independent antibody production in lake trout
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|c 2012
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 14.03.2013
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|a Date Revised 30.09.2020
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|a published: Print
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|a Citation Status MEDLINE
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|a Lake trout Salvelinus namaycush on thiamine-replete and thiamine-depleted diets were evaluated for the effects of thiamine status on in vivo responses to the T-dependent antigen trinitophenol (TNP)-keyhole limpet hemocyanin (TNP-KLH), the T-independent antigen trinitrophenol-lipolysaccaharide (TNP-LPS), or Dulbecco's phosphate-buffered saline (DPBS; negative control fish). Plasma antibody concentrations were evaluated for possible differences in total anti-TNP activity as well as differences in response kinetics. Associations between anti-TNP activity and muscle and liver thiamine concentrations as well as ratios of muscle-to-liver thiamine to anti-TNP activity were also examined. Thiamine-depleted lake trout that were injected with TNP-LPS exhibited significantly more anti-TNP activity than thiamine-replete fish. The depleted fish injected with TNP-LPS also exhibited significantly different response kinetics relative to thiamine-replete lake trout. No differences in activity or kinetics were observed between the thiamine-replete and -depleted fish injected with TNP-KLH or in the DPBS negative controls. Anti-TNP activity in thiamine-depleted lake trout injected with TNP-KLH was positively associated with muscle thiamine pyrophosphate (thiamine diphosphate; TPP) concentration. A negative association was observed between the ratio of muscle-to-liver TPP and T-independent responses. No significant associations between anti-TNP activity and tissue thiamine concentration were observed in the thiamine-replete fish. We demonstrated that thiamine deficiency leads to alterations in both T-dependent and T-independent immune responses in lake trout
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|a Controlled Clinical Trial
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Antibodies
|2 NLM
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|a Picrates
|2 NLM
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|a Hemocyanins
|2 NLM
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|a 9013-72-3
|2 NLM
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|a picric acid
|2 NLM
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| 650 |
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|a A49OS0F91S
|2 NLM
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| 650 |
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|a keyhole-limpet hemocyanin
|2 NLM
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| 650 |
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|a FV4Y0JO2CX
|2 NLM
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| 650 |
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|a Thiamine
|2 NLM
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| 650 |
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|a X66NSO3N35
|2 NLM
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| 700 |
1 |
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|a Honeyfield, Dale C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Densmore, Christine L
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Iwanowicz, Luke R
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Journal of aquatic animal health
|d 1998
|g 24(2012), 4 vom: 16. Dez., Seite 258-73
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|x 0899-7659
|7 nnns
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| 773 |
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|g volume:24
|g year:2012
|g number:4
|g day:16
|g month:12
|g pages:258-73
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|u http://dx.doi.org/10.1080/08997659.2012.713890
|3 Volltext
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