Lipid rearrangement in DSPC/DMPC bilayers : a neutron reflectometry study
Lipid translocation in membranes is still far from being understood and well characterized for natural cell membranes as well as for simpler bilayer model systems. Several discrepancies with respect to its occurrence and its characteristic time scale are present in the literature. In the current wor...
| Publié dans: | Langmuir : the ACS journal of surfaces and colloids. - 1985. - 28(2012), 45 vom: 13. Nov., Seite 15922-8 |
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| Auteur principal: | |
| Autres auteurs: | , |
| Format: | Article en ligne |
| Langue: | English |
| Publié: |
2012
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| Accès à la collection: | Langmuir : the ACS journal of surfaces and colloids |
| Sujets: | Journal Article Lipid Bilayers Phosphatidylcholines 1,2-distearoyllecithin EAG959U971 Dimyristoylphosphatidylcholine U86ZGC74V5 Silicon Z4152N8IUI |
| Résumé: | Lipid translocation in membranes is still far from being understood and well characterized for natural cell membranes as well as for simpler bilayer model systems. Several discrepancies with respect to its occurrence and its characteristic time scale are present in the literature. In the current work, the structural changes induced by lipid rearrangement in a distearoyl-/dimyristoyl-phosphocholine binary lipid system have been addressed by means of neutron reflectivity. It has been shown that a fast, spontaneous compositional reorganization with lipid transfer between the two leaflets of the bilayer takes place only when the lipid species are both in the fluid phase. This process has been identified as the so-called lipid flip-flop. Moreover, the influence of the preparation protocol on the structural properties of the system has been investigated |
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| Description: | Date Completed 19.04.2013 Date Revised 16.10.2018 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1520-5827 |
| DOI: | 10.1021/la303662e |