Flow-directed assembly of block copolymer vesicles in the lab-on-a-chip
We demonstrate a microfluidic approach to the production of block copolymer vesicles via flow-directed self-assembly in a segmented gas-liquid device. Chemical conditions that favor spherical micelles in the bulk are found to yield a nearly pure population of vesicles on a chip-a transformation of t...
| Veröffentlicht in: | Langmuir : the ACS journal of surfaces and colloids. - 1992. - 28(2012), 45 vom: 13. Nov., Seite 15756-61 |
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| Weitere Verfasser: | , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2012
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| Zugriff auf das übergeordnete Werk: | Langmuir : the ACS journal of surfaces and colloids |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't Polymers |
| Zusammenfassung: | We demonstrate a microfluidic approach to the production of block copolymer vesicles via flow-directed self-assembly in a segmented gas-liquid device. Chemical conditions that favor spherical micelles in the bulk are found to yield a nearly pure population of vesicles on a chip-a transformation of two full morphological steps-because of a coalescence mechanism enabled by high shear. The production of polymeric vesicles via top-down control in a microfluidic device enables new processing routes to applications including drug delivery formulations in the lab-on-a-chip |
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| Beschreibung: | Date Completed 19.04.2013 Date Revised 13.11.2012 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1520-5827 |
| DOI: | 10.1021/la303655s |