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231224s2012 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2012.07.017
|2 doi
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|a pubmed25n0739.xml
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|a (DE-627)NLM221848134
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|a (NLM)23069648
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|a (PII)S1521-6616(12)00192-1
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a He, Yin-Yan
|e verfasserin
|4 aut
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| 245 |
1 |
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|a The decidual stromal cells-secreted CCL2 induces and maintains decidual leukocytes into Th2 bias in human early pregnancy
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|c 2012
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 04.01.2013
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|a Date Revised 02.12.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2012 Elsevier Inc. All rights reserved.
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|a The precise mechanism of characteristic Th2 predominance at maternal-fetal interface remains unresolved. In the present study, we investigated roles of the decidua-derived CCL2 in Th2 predominance at maternal-fetal interface. FCM shows that 55% CD56(+)CD16(-)CD3(-) decidual NK, 52% CD4(+) T cells and 75% CD14(+) monocytes express CCR2. Recombinant human CCL2 (rhCCL2) and the decidual stromal cells (DSCs)-derived supernatant can enhance proliferation and inhibit apoptosis of these decidual leukocytes (DLCs), and promote Th2 cytokines production, IL-4 and IL-10, with an increase in GATA-3 transcription. They also inhibit the secretion of Th1 cytokines, TNF-α and IFN-γ, with a decrease in T-bet transcription It is concluded that the secreted CCL2 by decidual stromal cells increases GATA-3 transcription and decreases T-bet transcription in the decidual leukocytes, which contributes to Th2 polarization at maternal-fetal interface. Furthermore, the Th2 cytokines, IL-4 and IL-10, rather than Th1 cytokines, was shown to increase CCL2 secretion of DSC
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Antigens, CD
|2 NLM
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| 650 |
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|a CCL2 protein, human
|2 NLM
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| 650 |
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|a CCR2 protein, human
|2 NLM
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| 650 |
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|a Chemokine CCL2
|2 NLM
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| 650 |
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|a Culture Media, Conditioned
|2 NLM
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| 650 |
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7 |
|a GATA3 Transcription Factor
|2 NLM
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| 650 |
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|a Receptors, CCR2
|2 NLM
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| 650 |
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7 |
|a Recombinant Proteins
|2 NLM
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| 700 |
1 |
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|a He, Xiao-Ju
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Guo, Pei-Fen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Du, Mei-Rong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shao, Jun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Ming-Qing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Da-Jin
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 145(2012), 2 vom: 05. Nov., Seite 161-73
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
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| 773 |
1 |
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|g volume:145
|g year:2012
|g number:2
|g day:05
|g month:11
|g pages:161-73
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2012.07.017
|3 Volltext
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|d 145
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|e 2
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|h 161-73
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