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231224s2012 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2012.09.003
|2 doi
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|a pubmed24n0739.xml
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|a eng
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| 100 |
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|a Stone, Brad
|e verfasserin
|4 aut
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|a Identification of novel HLA class II target epitopes for generation of donor-specific T regulatory cells
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|c 2012
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 04.01.2013
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|a Date Revised 16.11.2017
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2012 Elsevier Inc. All rights reserved.
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|a Therapies capable of generating host T regulatory cells (T(R)) responsive to donor-specific HLA-class II minor histocompatibility antigens have the potential to promote tolerance of a transplanted organ. Our group has developed a novel approach for the identification of potentially therapeutic T(R) target antigens. We perform parallel non-synonymous SNP genotyping of HLA-identical subject pairs to identify peptide variations expressed by only one of the two subjects. Variant peptide pairs are then evaluated for binding a shared HLA-class II allele. Minor peptides predicted to bind HLA-class II with greater affinity than the common variant peptide are tested for HLA class II binding and in vitro induction of suppressive CD4+ T cells. Using this approach we have identified multiple pairs of variant peptides capable of differential binding and induction of suppressive CD4+ T cells. These data demonstrate the feasibility of identifying potentially therapeutic HLA class II minor antigens for generation of donor-specific T(R)
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a CD4 Antigens
|2 NLM
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|a Epitopes, T-Lymphocyte
|2 NLM
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| 650 |
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|a HLA-DRB1 Chains
|2 NLM
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| 650 |
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|a Peptides
|2 NLM
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| 650 |
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|a Interferon-gamma
|2 NLM
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|a 82115-62-6
|2 NLM
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| 700 |
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|a Rieck, Mary
|e verfasserin
|4 aut
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|a Rawlings, Crystal A
|e verfasserin
|4 aut
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| 700 |
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|a Kas, Arnold
|e verfasserin
|4 aut
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| 700 |
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|a Shendure, Jay
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jones, Hywel
|e verfasserin
|4 aut
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| 700 |
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|a Buckner, Jane H
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 145(2012), 2 vom: 07. Nov., Seite 153-60
|w (DE-627)NLM098196855
|x 1521-7035
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|g volume:145
|g year:2012
|g number:2
|g day:07
|g month:11
|g pages:153-60
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|u http://dx.doi.org/10.1016/j.clim.2012.09.003
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