Complex stiffness gradient substrates for studying mechanotactic cell migration

Complex stiffness gradient substrates for studying mechanotactic cell migration

Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 24(2012), 45 vom: 27. Nov., Seite 6059-64
1. Verfasser: Kuo, Cheng-Hwa R (VerfasserIn)
Weitere Verfasser: Xian, Jian, Brenton, James D, Franze, Kristian, Sivaniah, Easan
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2012
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Acrylic Resins polyacrylamide gels
Beschreibung
Zusammenfassung:Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Polyacrylamide gels are cast upon a stiff support with controlled topography, resulting in a thin gel layer of variable height. The topographical profiles project a stiffness map onto the gel, resulting in controlled linear and non-linear 2D stiffness gradients. Fibroblasts, which migrate towards stiffer substrates, accumulate in areas with a gel thickness below 15 μm
Beschreibung:Date Completed 01.05.2013
Date Revised 17.03.2022
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201202520