|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM220538085 |
| 003 |
DE-627 |
| 005 |
20231224045700.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231224s2012 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1016/j.clim.2012.07.010
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n0735.xml
|
| 035 |
|
|
|a (DE-627)NLM220538085
|
| 035 |
|
|
|a (NLM)22926077
|
| 035 |
|
|
|a (PII)S1521-6616(12)00185-4
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Bandyopadhyay, Gautam
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Trauma patients' elevated tumor necrosis related apoptosis inducing ligand (TRAIL) contributes to increased T cell apoptosis
|
| 264 |
|
1 |
|c 2012
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 27.11.2012
|
| 500 |
|
|
|a Date Revised 21.10.2021
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Copyright © 2012 Elsevier Inc. All rights reserved.
|
| 520 |
|
|
|a Immunosuppression resulting from excessive post-trauma apoptosis of hyperactivated T cells is controversial. TRAIL mediated T cell apoptosis decreases highly activated T cells' responses. Caspase-10, a particular TRAIL target, was increased in trauma patients' T cells with concomitantly elevated plasma TRAIL levels. These patients' T cells developed anergy, implicating increased TRAIL-mediated T cell apoptosis in post-trauma T cell anergy. Control T cells cultured with patients' sera containing high TRAIL levels increased their caspase-10 activity and apoptosis. Stimulated primary T cells are TRAIL apoptosis resistant. Increased plasma thrombospondin-1 and T cell expression of CD47, a thrombospondin-1 receptor, preceded patients' T cell anergy. CD47 triggering of T cells increased their sensitivity to TRAIL-induced apoptosis. Augmentation of T cell TRAIL-induced apoptosis was secondary to CD47 triggered activation of the Src homology-containing phosphatase-1 (SHP-1) and was partially blocked by a SHP-1 inhibitor. We suggest that combined post-trauma CD47 triggering, SHP-1 mediated NFκB suppression, and elevated TRAIL levels increase patients' CD47 expressing T cell apoptosis, thus contributing to subsequent T cell anergy
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, N.I.H., Extramural
|
| 650 |
|
7 |
|a CD47 Antigen
|2 NLM
|
| 650 |
|
7 |
|a CD47 protein, human
|2 NLM
|
| 650 |
|
7 |
|a Enzyme Inhibitors
|2 NLM
|
| 650 |
|
7 |
|a NF-kappa B
|2 NLM
|
| 650 |
|
7 |
|a Recombinant Proteins
|2 NLM
|
| 650 |
|
7 |
|a TNF-Related Apoptosis-Inducing Ligand
|2 NLM
|
| 650 |
|
7 |
|a TNFSF10 protein, human
|2 NLM
|
| 650 |
|
7 |
|a Thrombospondin 1
|2 NLM
|
| 650 |
|
7 |
|a PTPN6 protein, human
|2 NLM
|
| 650 |
|
7 |
|a EC 3.1.3.48
|2 NLM
|
| 650 |
|
7 |
|a Protein Tyrosine Phosphatase, Non-Receptor Type 6
|2 NLM
|
| 650 |
|
7 |
|a EC 3.1.3.48
|2 NLM
|
| 650 |
|
7 |
|a Caspase 10
|2 NLM
|
| 650 |
|
7 |
|a EC 3.4.22.-
|2 NLM
|
| 650 |
|
7 |
|a CASP10 protein, human
|2 NLM
|
| 650 |
|
7 |
|a EC 3.4.22.63
|2 NLM
|
| 700 |
1 |
|
|a Bankey, Paul E
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Miller-Graziano, Carol L
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 145(2012), 1 vom: 28. Okt., Seite 44-54
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
|
| 773 |
1 |
8 |
|g volume:145
|g year:2012
|g number:1
|g day:28
|g month:10
|g pages:44-54
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2012.07.010
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 145
|j 2012
|e 1
|b 28
|c 10
|h 44-54
|