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231224s2012 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2012.08.002
|2 doi
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|a pubmed25n0735.xml
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|a (DE-627)NLM220501408
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|a (NLM)22922271
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|a (PII)S1521-6616(12)00194-5
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Andrade, Regis M
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a High IL-10 production by aged AIDS patients is related to high frequency of Tr-1 phenotype and low in vitro viral replication
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|c 2012
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 27.11.2012
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|a Date Revised 17.09.2012
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2012 Elsevier Inc. All rights reserved.
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|a This work aims to elucidate the effects of age and HIV-1 infection on the frequency and function of T cell subsets in response to HIV-specific and non-specific stimuli. As compared with the younger AIDS group, the frequencies of naive and central memory T cells were significantly lower in aged AIDS patients. Although there was also a dramatic loss of classical CD4(+)FoxP3(+)CD25(+)Treg cells in this patient group, high frequencies of IL-10-producing CD4(+)FoxP3(-) T cells were observed. In our system, the increased production of IL-10 in aged AIDS patients was mainly derived from Env-specific CD4(+)FoxP3(-)CD152(+) T cells. Interestingly, while the blockade of IL-10 activity by monoclonal antibody clearly enhanced the release of IL-6 and IL-1β by Env-stimulated PBMC cultures from aged AIDS patients, this monoclonal antibody enhanced in vitro HIV-1-replication. In conclusion, HIV infection and aging undoubtedly contribute synergistically to a complex immune dysfunction in T cell compartment of HAART-treated older HIV-infected individuals
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|a Journal Article
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Antibodies, Monoclonal
|2 NLM
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| 650 |
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7 |
|a Antiviral Agents
|2 NLM
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| 650 |
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|a IL10 protein, human
|2 NLM
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| 650 |
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7 |
|a IL6 protein, human
|2 NLM
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| 650 |
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7 |
|a Interleukin-1beta
|2 NLM
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| 650 |
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7 |
|a Interleukin-6
|2 NLM
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| 650 |
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7 |
|a Interleukin-10
|2 NLM
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| 650 |
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7 |
|a 130068-27-8
|2 NLM
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| 700 |
1 |
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|a Hygino, Joana
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kasahara, Taissa M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Vieira, Morgana M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xavier, Luciana F
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Blanco, Bernardo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Damasco, Paulo V
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Silva, Rodrigo M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lima, Dirce B
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Oliveira, Ariane L
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lemos, Alberto S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Andrade, Arnaldo F B
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bento, Cleonice A M
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 145(2012), 1 vom: 24. Okt., Seite 31-43
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:145
|g year:2012
|g number:1
|g day:24
|g month:10
|g pages:31-43
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2012.08.002
|3 Volltext
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 145
|j 2012
|e 1
|b 24
|c 10
|h 31-43
|