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231224s2012 xx |||||o 00| ||eng c |
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|a 10.1109/TUFFC.2012.2374
|2 doi
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|e rakwb
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|a eng
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|a Gudur, Madhu Sudhan Reddy
|e verfasserin
|4 aut
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|a High-frequency rapid B-mode ultrasound imaging for real-time monitoring of lesion formation and gas body activity during high-intensity focused ultrasound ablation
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|c 2012
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|a Text
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 17.12.2012
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|a Date Revised 25.11.2016
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|a published: Print
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|a Citation Status MEDLINE
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|a The goal of this study was to examine the ability of high-frame-rate, high-resolution imaging to monitor tissue necrosis and gas-body activities formed during high-intensity focused ultrasound (HIFU) application. Ex vivo porcine cardiac tissue specimens (n = 24) were treated with HIFU exposure (4.33 MHz, 77 to 130 Hz pulse repetition frequency (PRF), 25 to 50% duty cycle, 0.2 to 1 s, 2600 W/cm(2)). RF data from B-mode ultrasound imaging were obtained before, during, and after HIFU exposure at a frame rate ranging from 77 to 130 Hz using an ultrasound imaging system with a center frequency of 55 MHz. The time history of changes in the integrated backscatter (IBS), calibrated spectral parameters, and echo-decorrelation parameters of the RF data were assessed for lesion identification by comparison against gross sections. Temporal maximum IBS with +12 dB threshold achieved the best identification with a receiver-operating characteristic (ROC) curve area of 0.96. Frame-to-frame echo decorrelation identified and tracked transient gas-body activities. Macroscopic (millimeter-sized) cavities formed when the estimated initial expansion rate of gas bodies (rate of expansion in lateral-to-beam direction) crossed 0.8 mm/s. Together, these assessments provide a method for monitoring spatiotemporal evolution of lesion and gas-body activity and for predicting macroscopic cavity formation
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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|a Gases
|2 NLM
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|a Kumon, Ronald E
|e verfasserin
|4 aut
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|a Zhou, Yun
|e verfasserin
|4 aut
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|a Deng, Cheri X
|e verfasserin
|4 aut
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|i Enthalten in
|t IEEE transactions on ultrasonics, ferroelectrics, and frequency control
|d 1986
|g 59(2012), 8 vom: 24. Aug., Seite 1687-99
|w (DE-627)NLM098181017
|x 1525-8955
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|g volume:59
|g year:2012
|g number:8
|g day:24
|g month:08
|g pages:1687-99
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|u http://dx.doi.org/10.1109/TUFFC.2012.2374
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