Chloroform-enhanced incorporation of hydrophobic gold nanocrystals into dioleoylphosphatidylcholine (DOPC) vesicle membranes

Vesicles of dioleoylphosphatidylcholine (DOPC) formed by extrusion (liposomes) with hydrophobic alkanethiol-capped Au nanocrystals were studied. Dodecanethiol-capped 1.8-nm-diameter Au nanocrystals accumulate in the lipid bilayer, but only when dried lipid-nanocrystal films were annealed with chloro...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 28(2012), 36 vom: 11. Sept., Seite 12971-81
1. Verfasser: Rasch, Michael R (VerfasserIn)
Weitere Verfasser: Yu, Yixuan, Bosoy, Christian, Goodfellow, Brian W, Korgel, Brian A
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2012
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Liposomes Phosphatidylcholines Sulfhydryl Compounds dodecylmercaptan 112-55-0 Gold 7440-57-5 mehr... Chloroform 7V31YC746X 1,2-oleoylphosphatidylcholine EDS2L3ODLV
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245 1 0 |a Chloroform-enhanced incorporation of hydrophobic gold nanocrystals into dioleoylphosphatidylcholine (DOPC) vesicle membranes 
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520 |a Vesicles of dioleoylphosphatidylcholine (DOPC) formed by extrusion (liposomes) with hydrophobic alkanethiol-capped Au nanocrystals were studied. Dodecanethiol-capped 1.8-nm-diameter Au nanocrystals accumulate in the lipid bilayer, but only when dried lipid-nanocrystal films were annealed with chloroform prior to hydration. Without chloroform annealing, the Au nanocrystals phase separate from DOPC and do not load into the liposomes. Au nanocrystals with slightly longer capping ligands of hexadecanethiol or with a larger diameter of 4.1 nm disrupted vesicle formation and created lipid assemblies with many internal lamellar attachments 
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650 4 |a Research Support, N.I.H., Extramural 
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700 1 |a Yu, Yixuan  |e verfasserin  |4 aut 
700 1 |a Bosoy, Christian  |e verfasserin  |4 aut 
700 1 |a Goodfellow, Brian W  |e verfasserin  |4 aut 
700 1 |a Korgel, Brian A  |e verfasserin  |4 aut 
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