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231224s2012 xx |||||o 00| ||eng c |
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7 |
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|a 10.1021/la302588f
|2 doi
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|a pubmed24n0733.xml
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|a DE-627
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|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Liu, Zhi
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Nonionic block copolymers assemble on the surface of protein bionanoparticle
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|c 2012
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 28.12.2012
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|a Date Revised 21.08.2012
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Efficient delivery of therapeutic proteins to a target site remains a challenge due to rapid clearance from the body. Here, we selected tobacco mosaic virus (TMV) as a model protein system to investigate the interactions between the protein and a nonionic block copolymer as a possible protecting agent for the protein. By varying the temperature, we were able to obtain core-shell structures based on hydrophobic interactions among PO blocks and noncovalent interactions between TMV and EO blocks. The protein-polymer interactions were characterized by dynamic light scattering and isothermal titration calorimetry. This study establishes principles for the possible design of clinically useful protein delivery systems
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Micelles
|2 NLM
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|a Viral Proteins
|2 NLM
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|a Poloxamer
|2 NLM
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| 650 |
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|a 106392-12-5
|2 NLM
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| 700 |
1 |
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|a Gu, Jingxia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Man
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jiang, Shidong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Dayong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Qian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Niu, Zhongwei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Yong
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 28(2012), 33 vom: 21. Aug., Seite 11957-61
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:28
|g year:2012
|g number:33
|g day:21
|g month:08
|g pages:11957-61
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| 856 |
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|u http://dx.doi.org/10.1021/la302588f
|3 Volltext
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