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231224s2012 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2012.06.009
|2 doi
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|a pubmed25n0732.xml
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|a (DE-627)NLM219758352
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|a (NLM)22836084
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Kim, Doo-Jin
|e verfasserin
|4 aut
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| 245 |
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|a Delivery of IL-12p40 ameliorates DSS-induced colitis by suppressing IL-17A expression and inflammation in the intestinal mucosa
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|c 2012
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 07.11.2012
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|a Date Revised 01.12.2018
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|a published: Print-Electronic
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|a ErratumIn: Clin Immunol. 2012 Nov;145(2):174-5
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2012 Elsevier Inc. All rights reserved.
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|a IL-12p40 homodimer is a natural antagonist of IL-12 and IL-23, which are potent pro-inflammatory cytokines required for Th1 and Th17 immune responses, respectively. It has been reported that Th17 response is involved in inflammatory bowel disease (IBD), a chronic disorder of the digestive system with steadily increasing incidence. Here, we investigated the effects of IL-12p40 delivered via recombinant adenovirus (rAd/IL-12p40) or mesenchymal stem cells (MSC/IL-12p40) in a dextran sulfate sodium salt (DSS)-induced colitis model. Injection of rAd/IL-12p40 or MSC/IL-12p40 efficiently attenuated colitis symptoms and tissue damage, leading to an increased survival rate. Moreover, IL-12p40 delivery suppressed IL-17A, but enhanced IFN-γ production from mesenteric lymph node cells, supporting the preferential suppression of IL-23 by IL-12p40 homodimer in vitro and the suppression of Th17 responses in vivo. Our results demonstrate that IL-12p40 delivery ameliorates DSS-induced colitis by suppressing IL-17A production and inflammation in the intestinal mucosa, providing an effective new therapeutic strategy for IBDs
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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7 |
|a Interleukin-12 Subunit p40
|2 NLM
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| 650 |
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7 |
|a Interleukin-17
|2 NLM
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| 650 |
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7 |
|a Interleukin-23
|2 NLM
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| 650 |
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7 |
|a Interleukin-12
|2 NLM
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| 650 |
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7 |
|a 187348-17-0
|2 NLM
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| 650 |
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|a Interferon-gamma
|2 NLM
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| 650 |
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7 |
|a 82115-62-6
|2 NLM
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| 650 |
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7 |
|a Dextran Sulfate
|2 NLM
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| 650 |
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7 |
|a 9042-14-2
|2 NLM
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| 700 |
1 |
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|a Kim, Kwang-Soon
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Song, Mi-Young
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Seo, Sang-Hwan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kim, Su-Jin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Bo-Gie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jang, Myoung-Ho
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sung, Young-Chul
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 144(2012), 3 vom: 01. Sept., Seite 190-9
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:144
|g year:2012
|g number:3
|g day:01
|g month:09
|g pages:190-9
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2012.06.009
|3 Volltext
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