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231224s2012 xx |||||o 00| ||eng c |
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|a 10.1021/la302455y
|2 doi
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|a pubmed24n0732.xml
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|a (DE-627)NLM219747679
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|a (NLM)22834790
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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1 |
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|a Ye, Chunhong
|e verfasserin
|4 aut
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| 245 |
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|a Permeability and micromechanical properties of silk ionomer microcapsules
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|c 2012
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 28.12.2012
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|a Date Revised 25.11.2016
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a We studied the pH-responsive behavior of layer-by-layer (LbL) microcapsules fabricated from silk fibroin chemically modified with different poly amino acid side chains: cationic (silk-poly L-lysine, SF-PL) or anionic (silk-poly-L-glutamic acid, SF-PG). We observed that stable ultrathin shell microcapsules can be assembled with a dramatic increase in swelling, thickness, and microroughness at extremely acidic (pH < 2.5) and basic (pH > 11.0) conditions without noticeable disintegration. These changes are accompanied by dramatic changes in shell permeability with a 2 orders of magnitude increase in the diffusion coefficient. Moreover, the silk ionomer shells undergo remarkable softening with a drop in Young's modulus by more than 1 order of magnitude due to the swelling, stretching, and increase in material porosity. The ability to control permeability and mechanical properties over a wide range for the silk-based microcapsules, with distinguishing stability under harsh environmental conditions, provides an important system for controlled loading and release and applications in bioengineering
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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|a Research Support, U.S. Gov't, Non-P.H.S.
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|a Amino Acids
|2 NLM
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|a Capsules
|2 NLM
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|a Polymers
|2 NLM
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|a Polyethyleneimine
|2 NLM
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|a 9002-98-6
|2 NLM
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|a Fibroins
|2 NLM
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|a 9007-76-5
|2 NLM
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| 700 |
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|a Drachuk, Irina
|e verfasserin
|4 aut
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|a Calabrese, Rossella
|e verfasserin
|4 aut
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| 700 |
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|a Dai, Hongqi
|e verfasserin
|4 aut
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| 700 |
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|a Kaplan, David L
|e verfasserin
|4 aut
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| 700 |
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|a Tsukruk, Vladimir V
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 28(2012), 33 vom: 21. Aug., Seite 12235-44
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:28
|g year:2012
|g number:33
|g day:21
|g month:08
|g pages:12235-44
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