Inversion of 1J(CC) correlations in 1,n-ADEQUATE spectra
Copyright © 2012 John Wiley & Sons, Ltd.
| Veröffentlicht in: | Magnetic resonance in chemistry : MRC. - 1985. - 50(2012), 8 vom: 30. Aug., Seite 563-8 |
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| 1. Verfasser: | |
| Weitere Verfasser: | , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2012
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| Zugriff auf das übergeordnete Werk: | Magnetic resonance in chemistry : MRC |
| Schlagworte: | Journal Article Protons Pyrrolizidine Alkaloids Carbon 7440-44-0 retrorsine XJ86XWL8IY |
| Zusammenfassung: | Copyright © 2012 John Wiley & Sons, Ltd. ADEQUATE experiments provide an alternative to the more commonly employed GHMBC experiment for the establishment of long-range heteronuclear connectivities. The 1,1-ADEQUATE experiment allows the unequivocal identification of both protonated and non-protonated carbon resonances adjacent to a protonated carbon. The 1,n-ADEQUATE experiment establishes correlations via an initial (1)J(CH) heteronuclear transfer followed by an (n)J(CC) out-and-back transfer, most typically, via three carbon-carbon bonds. Hence, the 1,n-ADEQUATE experiment allows the equivalent of (4)J(CH) heteronuclear correlations to be probed when they are not observed in a GHMBC spectrum. Aside from the lower sensitivity of the 1,n-ADEQUATE experiment relative to GHMBC experiments, the interpretation of the former is also complicated by the 'leakage' of (1)J(CC) correlations into the spectrum that must be identified. A method for the inversion of (1)J(CC) correlations to facilitate the interpretation of 1,n-ADEQUATE spectra is presented that allows a single experiment to be performed to access (1)J(CC) and (n)J(CC) correlation information |
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| Beschreibung: | Date Completed 01.04.2013 Date Revised 18.07.2012 published: Print Citation Status MEDLINE |
| ISSN: | 1097-458X |
| DOI: | 10.1002/mrc.3840 |