Consequences of inhibiting amyloid precursor protein processing enzymes on synaptic function and plasticity

Alzheimer's disease (AD) is a neurodegenerative disease, one of whose major pathological hallmarks is the accumulation of amyloid plaques comprised of aggregated β-amyloid (Aβ) peptides. It is now recognized that soluble Aβ oligomers may lead to synaptic dysfunctions early in AD pathology prece...

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Veröffentlicht in:	Neural plasticity. - 1998. - 2012(2012) vom: 01., Seite 272374
1. Verfasser:	Wang, Hui (VerfasserIn)
Weitere Verfasser:	Megill, Andrea, He, Kaiwen, Kirkwood, Alfredo, Lee, Hey-Kyoung
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2012
Zugriff auf das übergeordnete Werk:	Neural plasticity
Schlagworte:	Journal Article Research Support, N.I.H., Extramural Review Amyloid beta-Peptides Amyloid beta-Protein Precursor Enzyme Inhibitors Presenilins Amyloid Precursor Protein Secretases EC 3.4.- Aspartic Acid Endopeptidases mehr... EC 3.4.23.- BACE1 protein, human EC 3.4.23.46