Polyaspartamide derivative nanoparticles with tunable surface charge achieve highly efficient cellular uptake and low cytotoxicity
Cationic nanocarrier mediated intracellular therapeutic agent delivery acts as a double-edged sword: the carriers promote cellular uptake, but interact nonspecifically and strongly with negatively charged endogenic proteins and cell membranes, which results in aggregates and high cytotoxicity. The p...
| Publié dans: | Langmuir : the ACS journal of surfaces and colloids. - 1985. - 28(2012), 31 vom: 07. Aug., Seite 11310-8 |
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| Auteur principal: | |
| Autres auteurs: | , |
| Format: | Article en ligne |
| Langue: | English |
| Publié: |
2012
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| Accès à la collection: | Langmuir : the ACS journal of surfaces and colloids |
| Sujets: | Journal Article Research Support, Non-U.S. Gov't Drug Carriers Ethylenediamines Peptides polyaspartate 26063-13-8 tetraethylenepentamine YZD1C9KQ28 |
| Accès en ligne |
Volltext |