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01000naa a22002652 4500 |
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NLM219184534 |
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231224s2012 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1021/la3020817
|2 doi
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|a pubmed24n0730.xml
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|a (DE-627)NLM219184534
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|a (NLM)22765230
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Yuan, Liang
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Self-assembly of a diblock copolymer with pendant disulfide bonds and chromophore groups
|b a new platform for fast release
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| 264 |
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1 |
|c 2012
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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| 500 |
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|a Date Completed 20.12.2012
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|a Date Revised 31.07.2012
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a An amphiphilic block copolymer comprising poly(ethylene glycol) (PEG) and poly(2-(methacryloyl)oxyethyl-2'-hydroxyethyl disulfide) (PMAOHD) blocks was synthesized by atom transfer radical polymerization (ATRP). Pyrenebutyric acid was conjugated to the block copolymer by esterification, and a block copolymer with pendant disulfide bonds and pyrenyl groups (PEG-b-P(MAOHD-g-Py)) was obtained. (1)H NMR and gel permeation chromatography (GPC) results demonstrated the successful synthesis of the block copolymer. The cleavage of the disulfide bonds and the degrafting of the pyrenyl groups were investigated in THF and a THF/methanol mixture. Fluorescence spectroscopy, GPC, and (1)H NMR results demonstrated fast cleavage of the disulfide bonds by Bu(3)P in THF. Fluorescence results showed the ratio of the intensity of the excimer peak to the monomer peak decreased rapidly within 20 min. GPC traces of the block copolymer moved to a long retention time region after addition of Bu(3)P, indicating the cleavage of the disulfide bonds and the degrafting of the pyrenyl groups. PEG-b-P(MAOHD-g-Py) can self-assemble into micelles with poly(MAOHD-g-Py) cores and PEG coronae in a mixture of methanol and THF (9:1 by volume). The dissociation of the micelles in the presence of Bu(3)P was investigated. After cleavage of the disulfide bonds in the micellar cores, a pyrene-containing small molecular compound and a block copolymer with pendant thiol groups were produced. Transmission electron microscopy (TEM), dynamic light scattering (DLS), and (1)H NMR were employed to track the dissociation of the polymeric micelles. All the techniques demonstrated the dissociation of the micelles and the fast release of pyrenyl groups from the micelles
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|a Journal Article
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1 |
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|a Liu, Jingchuan
|e verfasserin
|4 aut
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1 |
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|a Wen, Jianguo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Hanying
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 28(2012), 30 vom: 31. Juli, Seite 11232-40
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:28
|g year:2012
|g number:30
|g day:31
|g month:07
|g pages:11232-40
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| 856 |
4 |
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|u http://dx.doi.org/10.1021/la3020817
|3 Volltext
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