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231224s2012 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2012.05.006
|2 doi
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|a pubmed24n0729.xml
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|a (DE-627)NLM21873039X
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|a (NLM)22710446
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Ramirez, Karina
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Intranasal vaccination with an adjuvanted Norwalk virus-like particle vaccine elicits antigen-specific B memory responses in human adult volunteers
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| 264 |
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1 |
|c 2012
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 19.10.2012
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| 500 |
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|a Date Revised 22.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2012 Elsevier Inc. All rights reserved.
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|a Noroviruses are the most frequent cause of acute gastroenteritis in humans of all ages. No vaccines are currently available. An intranasally delivered Norwalk (NV) virus-like particle (VLP) vaccine was recently shown to be well tolerated, immunogenic and to protect against infection in Phase 1 studies. Here, we examined B memory (B(M)) responses in volunteers who received the highest dosage levels of the NV-VLP vaccine (50 μg and 100 μg). We measured the frequency of NV-specific IgG and IgA-secreting B(M) cells in peripheral blood and the level of antibodies produced by these cells in culture. All subjects immunized with 100 μg of the NV-VLP vaccine and 90% of those who received 50 μg had significant IgA or IgG B(M) responses. The B(M) cell frequencies correlated with serum antibody levels and mucosally-primed antibody-secreting cell responses. This is the first demonstration of dose-dependent, functional B(M) responses in humans immunized intranasally with a NV-VLP vaccine
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Antigens, Viral
|2 NLM
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| 650 |
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7 |
|a Immunoglobulin A
|2 NLM
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| 650 |
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7 |
|a Immunoglobulin G
|2 NLM
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| 650 |
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7 |
|a Vaccines, Virus-Like Particle
|2 NLM
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| 650 |
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7 |
|a Viral Vaccines
|2 NLM
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| 700 |
1 |
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|a Wahid, Rezwanul
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Richardson, Charles
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bargatze, Robert F
|e verfasserin
|4 aut
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| 700 |
1 |
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|a El-Kamary, Samer S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sztein, Marcelo B
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pasetti, Marcela F
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 144(2012), 2 vom: 04. Aug., Seite 98-108
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:144
|g year:2012
|g number:2
|g day:04
|g month:08
|g pages:98-108
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| 856 |
4 |
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|u http://dx.doi.org/10.1016/j.clim.2012.05.006
|3 Volltext
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 144
|j 2012
|e 2
|b 04
|c 08
|h 98-108
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