β7 integrin controls immunogenic and tolerogenic mucosal B cell responses

β7 integrin controls immunogenic and tolerogenic mucosal B cell responses

Copyright © 2012 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 144(2012), 2 vom: 01. Aug., Seite 87-97
1. Verfasser: Schippers, Angela (VerfasserIn)
Weitere Verfasser: Kochut, Annika, Pabst, Oliver, Frischmann, Ursula, Clahsen, Thomas, Tenbrock, Klaus, Müller, Werner, Wagner, Norbert
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2012
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Immunoglobulin A, Secretory Immunoglobulin G Integrin beta Chains integrin beta7
Beschreibung
Zusammenfassung:Copyright © 2012 Elsevier Inc. All rights reserved.
IgA production in the gut-associated lymphoid tissue represents a pivotal defense mechanism against luminal pathogens. The other important challenge for the GALT is the induction of local and systemic hyporesponsiveness (tolerance) to dietary antigens and luminal bacterial flora to prevent allergies or deleterious immunologic reactions to food or environmental antigens. In this study we analyzed the impact of β7 integrin on immunogenic and tolerogenic B cell responses in the gastrointestinal tract. β7 integrin deficient mice failed to mount a normal intestinal IgA response to ovalbumin and cholera toxin, whereas the IgG response was unchanged in comparison to control mice. Oral B cell tolerance to ovalbumin, measured as the suppression of specific serum IgG responses, did not develop in the absence of β7 integrin. After adoptive transfer of spleen cells from β7 integrin +/+ mice into RAG-2 deficient or RAG-2/β7 integrin double deficient mice, only RAG-2 deficient mice were able to develop oral B cell tolerance. These observations suggest that β7 integrin expression on cells of the innate immune system contributes to the critical role of β7 integrin in the process of B cell tolerance
Beschreibung:Date Completed 19.10.2012
Date Revised 23.07.2012
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2012.05.008