miRNA in systemic lupus erythematosus
Copyright © 2012 Elsevier Inc. All rights reserved.
| Veröffentlicht in: | Clinical immunology (Orlando, Fla.). - 1999. - 144(2012), 1 vom: 27. Juli, Seite 26-31 |
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| Format: | Online-Aufsatz |
| Sprache: | English |
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2012
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| Zugriff auf das übergeordnete Werk: | Clinical immunology (Orlando, Fla.) |
| Schlagworte: | Journal Article Review MicroRNAs |
| Zusammenfassung: | Copyright © 2012 Elsevier Inc. All rights reserved. Since their recent discovery, the small noncoding RNA known as microRNAs (miRNA) have been reported to play a major role in the physiological control of gene expression and in the pathogenesis of malignant, infectious, and autoimmune disorders. In systemic lupus erythematosus (SLE), an autoimmune disease characterized by the presence of autoantibodies to multiple antigens, the role of miRNA as post-transcriptional regulators of different aspects of the disease process has recently emerged. This article reviews the pertinent literature and mechanisms of action of miRNA that have so far been associated with the pathogenesis of SLE |
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| Beschreibung: | Date Completed 23.08.2012 Date Revised 18.06.2012 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1521-7035 |
| DOI: | 10.1016/j.clim.2012.04.005 |