Associations of cytokines, sleep patterns, and neurocognitive function in youth with HIV infection

Associations of cytokines, sleep patterns, and neurocognitive function in youth with HIV infection

Copyright © 2012 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 144(2012), 1 vom: 27. Juli, Seite 13-23
1. Verfasser: Foster, Samuel B (VerfasserIn)
Weitere Verfasser: Lu, Ming, Glaze, Daniel G, Reuben, James M, Harris, Lynnette L, Cohen, Evan N, Lee, Bang-Ning, Zhao, Enxu, Paul, Mary E, Schwarzwald, Heidi, McMullen-Jackson, Chivon, Clark, Charla, Armstrong, F Daniel, Brouwers, Pim Y, Miller, Tracie L, Colin, Andrew A, Scott, Gwendolyn B, Shahzeidi, Shahriar, Willen, Elizabeth J, Asthana, Deshratn, Lipshultz, Steven E, Thompson, Bruce W, Shearer, William T
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2012
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Cytokines
LEADER 01000naa a22002652 4500
001 NLM21829011X
003 DE-627
005 20231224040031.0
007 cr uuu---uuuuu
008 231224s2012 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.clim.2012.04.004  |2 doi 
028 5 2 |a pubmed24n0727.xml 
035 |a (DE-627)NLM21829011X 
035 |a (NLM)22659030 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
100 1 |a Foster, Samuel B  |e verfasserin  |4 aut 
245 1 0 |a Associations of cytokines, sleep patterns, and neurocognitive function in youth with HIV infection 
264 1 |c 2012 
336 |a Text  |b txt  |2 rdacontent 
337 |a ƒaComputermedien  |b c  |2 rdamedia 
338 |a ƒa Online-Ressource  |b cr  |2 rdacarrier 
500 |a Date Completed 23.08.2012 
500 |a Date Revised 21.10.2021 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a Copyright © 2012 Elsevier Inc. All rights reserved. 
520 |a Youth infected with HIV at birth often have sleep disturbances, neurocognitive deficits, and abnormal psychosocial function which are associated with and possibly resulted from elevated blood cytokine levels that may lead to a decreased quality of life. To identify molecular pathways that might be associated with these disorders, we evaluated 38 HIV-infected and 35 uninfected subjects over 18-months for intracellular cytokine levels, sleep patterns and duration of sleep, and neurodevelopmental abilities. HIV infection was significantly associated with alterations of intracellular pro-inflammatory cytokines (TNF-α, IFN-γ, IL-12), sleep factors (total time asleep and daytime sleep patterns), and neurocognitive factors (parent and patient reported problems with socio-emotional, behavioral, and executive functions; working memory-mental fatigue; verbal memory; and sustained concentration and vigilance. By better defining the relationships between HIV infection, sleep disturbances, and poor psychosocial behavior and neurocognition, it may be possible to provide targeted pharmacologic and procedural interventions to improve these debilitating conditions 
650 4 |a Journal Article 
650 4 |a Research Support, N.I.H., Extramural 
650 4 |a Research Support, Non-U.S. Gov't 
650 7 |a Cytokines  |2 NLM 
700 1 |a Lu, Ming  |e verfasserin  |4 aut 
700 1 |a Glaze, Daniel G  |e verfasserin  |4 aut 
700 1 |a Reuben, James M  |e verfasserin  |4 aut 
700 1 |a Harris, Lynnette L  |e verfasserin  |4 aut 
700 1 |a Cohen, Evan N  |e verfasserin  |4 aut 
700 1 |a Lee, Bang-Ning  |e verfasserin  |4 aut 
700 1 |a Zhao, Enxu  |e verfasserin  |4 aut 
700 1 |a Paul, Mary E  |e verfasserin  |4 aut 
700 1 |a Schwarzwald, Heidi  |e verfasserin  |4 aut 
700 1 |a McMullen-Jackson, Chivon  |e verfasserin  |4 aut 
700 1 |a Clark, Charla  |e verfasserin  |4 aut 
700 1 |a Armstrong, F Daniel  |e verfasserin  |4 aut 
700 1 |a Brouwers, Pim Y  |e verfasserin  |4 aut 
700 1 |a Miller, Tracie L  |e verfasserin  |4 aut 
700 1 |a Colin, Andrew A  |e verfasserin  |4 aut 
700 1 |a Scott, Gwendolyn B  |e verfasserin  |4 aut 
700 1 |a Shahzeidi, Shahriar  |e verfasserin  |4 aut 
700 1 |a Willen, Elizabeth J  |e verfasserin  |4 aut 
700 1 |a Asthana, Deshratn  |e verfasserin  |4 aut 
700 1 |a Lipshultz, Steven E  |e verfasserin  |4 aut 
700 1 |a Thompson, Bruce W  |e verfasserin  |4 aut 
700 1 |a Shearer, William T  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Clinical immunology (Orlando, Fla.)  |d 1999  |g 144(2012), 1 vom: 27. Juli, Seite 13-23  |w (DE-627)NLM098196855  |x 1521-7035  |7 nnns 
773 1 8 |g volume:144  |g year:2012  |g number:1  |g day:27  |g month:07  |g pages:13-23 
856 4 0 |u http://dx.doi.org/10.1016/j.clim.2012.04.004  |3 Volltext 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_11 
912 |a GBV_ILN_24 
912 |a GBV_ILN_350 
951 |a AR 
952 |d 144  |j 2012  |e 1  |b 27  |c 07  |h 13-23