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231224s2012 xx |||||o 00| ||eng c |
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|a 10.1155/2012/581291
|2 doi
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|a eng
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|a Naqib, Faisal
|e verfasserin
|4 aut
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|a Molecular determinants of the spacing effect
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|c 2012
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|a Text
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 02.08.2012
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|a Date Revised 29.04.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Long-term memory formation is sensitive to the pattern of training sessions. Training distributed over time (spaced training) is superior at generating long-term memories than training presented with little or no rest interval (massed training). This spacing effect was observed in a range of organisms from invertebrates to humans. In the present paper, we discuss the evidence supporting cyclic-AMP response element-binding protein 2 (CREB), a transcription factor, as being an important molecule mediating long-term memory formation after spaced training. We also review the main upstream proteins that regulate CREB in different model organisms. Those include the eukaryotic translation initiation factor (eIF2α), protein phosphatase I (PP1), mitogen-activated protein kinase (MAPK), and the protein tyrosine phosphatase corkscrew. Finally, we discuss PKC activation and protein synthesis and degradation as mechanisms by which neurons decode the spacing intervals
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Review
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|a Cyclic AMP Response Element-Binding Protein
|2 NLM
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|a Transcription Factors
|2 NLM
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|a Protein Kinase C
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|a EC 2.7.11.13
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|a Mitogen-Activated Protein Kinases
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|a EC 2.7.11.24
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|a Protein Phosphatase 1
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|a EC 3.1.3.16
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|a Sossin, Wayne S
|e verfasserin
|4 aut
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|a Farah, Carole A
|e verfasserin
|4 aut
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|i Enthalten in
|t Neural plasticity
|d 1998
|g 2012(2012) vom: 01., Seite 581291
|w (DE-627)NLM098558390
|x 1687-5443
|7 nnas
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| 773 |
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|g volume:2012
|g year:2012
|g day:01
|g pages:581291
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|u http://dx.doi.org/10.1155/2012/581291
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|d 2012
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