Molecular determinants of the spacing effect
Long-term memory formation is sensitive to the pattern of training sessions. Training distributed over time (spaced training) is superior at generating long-term memories than training presented with little or no rest interval (massed training). This spacing effect was observed in a range of organis...
| Publié dans: | Neural plasticity. - 1998. - 2012(2012) vom: 01., Seite 581291 |
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| Auteur principal: | |
| Autres auteurs: | , |
| Format: | Article en ligne |
| Langue: | English |
| Publié: |
2012
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| Accès à la collection: | Neural plasticity |
| Sujets: | Journal Article Research Support, Non-U.S. Gov't Review Cyclic AMP Response Element-Binding Protein Transcription Factors Protein Kinase C EC 2.7.11.13 Mitogen-Activated Protein Kinases EC 2.7.11.24 Protein Phosphatase 1 |
| Résumé: | Long-term memory formation is sensitive to the pattern of training sessions. Training distributed over time (spaced training) is superior at generating long-term memories than training presented with little or no rest interval (massed training). This spacing effect was observed in a range of organisms from invertebrates to humans. In the present paper, we discuss the evidence supporting cyclic-AMP response element-binding protein 2 (CREB), a transcription factor, as being an important molecule mediating long-term memory formation after spaced training. We also review the main upstream proteins that regulate CREB in different model organisms. Those include the eukaryotic translation initiation factor (eIF2α), protein phosphatase I (PP1), mitogen-activated protein kinase (MAPK), and the protein tyrosine phosphatase corkscrew. Finally, we discuss PKC activation and protein synthesis and degradation as mechanisms by which neurons decode the spacing intervals |
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| Description: | Date Completed 02.08.2012 Date Revised 29.04.2023 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1687-5443 |
| DOI: | 10.1155/2012/581291 |