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231224s2012 xx |||||o 00| ||eng c |
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|a 10.1007/s10646-012-0916-1
|2 doi
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|a pubmed24n0724.xml
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|e rakwb
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|a eng
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|a Vellinger, Céline
|e verfasserin
|4 aut
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|a Antagonistic toxicity of arsenate and cadmium in a freshwater amphipod (Gammarus pulex)
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|c 2012
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 26.11.2012
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|a Date Revised 21.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Because toxicants rarely occur alone in the environment, a major challenge in risk assessment is to address the combined effects of chemicals on aquatic organisms. This work is aimed at investigating the joint toxicity action of binary mixtures of cadmium and arsenate on Gammarus pulex. Individuals were exposed during 240 h to four single arsenate or cadmium concentrations and binary mixtures of these metals according to a complete factorial plane. Observed mortality in binary mixtures was compared to observed mortality in single arsenate or cadmium exposures. In addition, interactive effects (antagonistic, additive or synergistic) were evaluated using a predictive model for the theoretically expected interactive effect of chemicals. For all the tested concentration combinations, we observed an antagonist 'between-metals' interaction on G. pulex mortality. This antagonistic effect was more marked for the lowest than for the highest (i.e. 1502.0 μg(AsV) L(-1) and 28.5 μg(Cd) L(-1)) tested concentrations of individual metals in binary mixtures. Metal concentrations in body tissues were evaluated and were significantly lower in binary mixtures than in single metal exposures at similar concentration, especially for combinations corresponding to the highest concentrations of both metals (1502.0 μg(AsV) L(-1) and 28.5 μg(Cd) L(-1)). Results were discussed in terms of (1) mechanisms of uptake and bioconcentration and (2) relationships between metal concentration in gammarid body and observed toxicity
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Arsenates
|2 NLM
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|a Cadmium
|2 NLM
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| 650 |
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|a 00BH33GNGH
|2 NLM
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|a arsenic acid
|2 NLM
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| 650 |
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|a N7CIZ75ZPN
|2 NLM
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| 700 |
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|a Parant, Marc
|e verfasserin
|4 aut
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|a Rousselle, Philippe
|e verfasserin
|4 aut
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|a Usseglio-Polatera, Philippe
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Ecotoxicology (London, England)
|d 1992
|g 21(2012), 7 vom: 14. Okt., Seite 1817-27
|w (DE-627)NLM098212214
|x 1573-3017
|7 nnns
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| 773 |
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|g volume:21
|g year:2012
|g number:7
|g day:14
|g month:10
|g pages:1817-27
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|u http://dx.doi.org/10.1007/s10646-012-0916-1
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