Cyanobacteria-blooming water samples from Lake Taihu induce endoplasmic reticulum stress in liver and kidney of mice

Cyanobacteria-blooming water samples from Lake Taihu induce endoplasmic reticulum stress in liver and kidney of mice

To investigate whether endoplasmic reticulum (ER) stress was involved in apoptosis induced by cyanobacteria-blooming water, healthy male ICR mice were fed with water samples from cyanobacteria-blooming regions of Lake Taihu (China), including Meiliang Bay (M1 and M2), central lake region (H), macrop...

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Veröffentlicht in:Ecotoxicology (London, England). - 1992. - 21(2012), 5 vom: 18. Juli, Seite 1495-503
1. Verfasser: Qin, Wendi (VerfasserIn)
Weitere Verfasser: Yang, Liuyan, Zhang, Xuxiang, Zhang, Zongyao, Xu, Lizhi, Wu, Jun, An, Jing, Wang, Yaping
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2012
Zugriff auf das übergeordnete Werk:Ecotoxicology (London, England)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Endoplasmic Reticulum Chaperone BiP HSP70 Heat-Shock Proteins Heat-Shock Proteins Hspa5 protein, mouse Membrane Proteins RNA, Messenger glucose-regulated proteins Water mehr... 059QF0KO0R Transcription Factor CHOP 147336-12-7 Casp12 protein, mouse EC 3.4.22.- Caspase 12
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100 1 |a Qin, Wendi  |e verfasserin  |4 aut 
245 1 0 |a Cyanobacteria-blooming water samples from Lake Taihu induce endoplasmic reticulum stress in liver and kidney of mice 
264 1 |c 2012 
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500 |a Date Revised 03.12.2021 
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500 |a Citation Status MEDLINE 
520 |a To investigate whether endoplasmic reticulum (ER) stress was involved in apoptosis induced by cyanobacteria-blooming water, healthy male ICR mice were fed with water samples from cyanobacteria-blooming regions of Lake Taihu (China), including Meiliang Bay (M1 and M2), central lake region (H), macrophyte-dominated Xukou Bay (X), and tap water (control group) for three consecutive months. Hepatic and renal mRNA and protein expression of ER stress signaling molecules were measured with quantitative real-time PCR and western blotting. Compared to macrophyte-dominated and control water samples, cyanobacteria-blooming water changed hepatic ER stress signaling molecules. M1 water treatment increased the mRNA and protein levels of glucose regulation protein 78 (GRP78) and C/EBP homologous protein (CHOP), and decreased the mRNA levels of B-cell lymphoma 2 (Bcl-2). M2 water treatment up-regulated GRP78 mRNA and protein expression, whereas H water treatment up-regulated mRNA and protein expression of GRP78 and caspase-12. Cyanobacteria-blooming water exposure also changed mRNA and protein expression of ER stress signaling molecules in the kidneys. M1 water exposure up-regulated GRP78 mRNA and protein expression and CHOP mRNA expression, whereas M2 water treatment up-regulated caspase-12 and Bcl-2 mRNA expression. M1 and M2 cyanobacteria-blooming water exposure significantly increased relative liver weights, and induced hepatic cell apoptosis. However, cyanobacteria-blooming water treatment did not change kidney weights, and did not induce renal apoptosis compared to macrophyte-dominated and control water samples. Hence, cyanobacteria-blooming water induces hepatic apoptosis via ER stress, and ER stress may play an important role in the apparent anti-apoptotic effects on renal cells exposed to cyanobacteria-blooming water 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
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650 7 |a Heat-Shock Proteins  |2 NLM 
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650 7 |a Water  |2 NLM 
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650 7 |a Casp12 protein, mouse  |2 NLM 
650 7 |a EC 3.4.22.-  |2 NLM 
650 7 |a Caspase 12  |2 NLM 
650 7 |a EC 3.4.22.-  |2 NLM 
700 1 |a Yang, Liuyan  |e verfasserin  |4 aut 
700 1 |a Zhang, Xuxiang  |e verfasserin  |4 aut 
700 1 |a Zhang, Zongyao  |e verfasserin  |4 aut 
700 1 |a Xu, Lizhi  |e verfasserin  |4 aut 
700 1 |a Wu, Jun  |e verfasserin  |4 aut 
700 1 |a An, Jing  |e verfasserin  |4 aut 
700 1 |a Wang, Yaping  |e verfasserin  |4 aut 
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773 1 8 |g volume:21  |g year:2012  |g number:5  |g day:18  |g month:07  |g pages:1495-503 
856 4 0 |u http://dx.doi.org/10.1007/s10646-012-0903-6  |3 Volltext 
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