Tailoring substrates for long-term organotypic culture of adult neuronal tissue

Tailoring substrates for long-term organotypic culture of adult neuronal tissue

Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 24(2012), 18 vom: 08. Mai, Seite 2399-403
1. Verfasser: Dallacasagrande, Valentina (VerfasserIn)
Weitere Verfasser: Zink, Mareike, Huth, Steven, Jakob, Alexander, Müller, Marcus, Reichenbach, Andreas, Käs, Josef A, Mayr, S G
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2012
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't titanium dioxide 15FIX9V2JP Titanium D1JT611TNE
Beschreibung
Zusammenfassung:Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Organotypic tissue cultures are highly promising for performing in vivo type studies in vitro. Currently, however, very limited survival times of only a few days for adult tissue often severely limit their application. Here, superhydrophilic nanostructured substrates with ideal material properties ensure tissue adhesion, essential for organotypic culture, while migration of single cells out of the tissue is hampered. Tuning substrate properties, for the first time, adult neuronal tissue could be cultured for 14 days with no indications of degeneration
Beschreibung:Date Completed 04.09.2012
Date Revised 30.09.2020
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201200816