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231224s2012 xx |||||o 00| ||eng c |
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|a 10.1007/s10646-012-0897-0
|2 doi
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|a pubmed24n0722.xml
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|a (DE-627)NLM216764467
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|a (NLM)22476697
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Baylay, A J
|e verfasserin
|4 aut
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| 245 |
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|a A metabolomics based test of independent action and concentration addition using the earthworm Lumbricus rubellus
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|c 2012
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 08.11.2012
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|a Date Revised 21.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a A major challenge in ecotoxicology is to understand the effects of multiple toxicants on organisms. Here we assess the effects on survival, weight change, cocoon production and metabolism caused by exposure to two similarly acting (imidacloprid/thiacloprid) and two dissimilarly acting (chlorpyrifos/Nickel) chemicals on the earthworm Lumbricus rubellus. We assessed the standard models of concentration addition (CA) and independent action (IA), in conjunction with a metabolomics based approach to elucidate mechanisms of effect. For imidacloprid and thiacloprid the reproductive effects indicated probable additivity. Although this suggests joint effects through a similar mechanism, metabolite changes for each pesticide actually indicated distinct effects. Further, earthworms exposed to a 0.5 toxic unit equitoxic mixture demonstrated metabolic effects intermediate between those for each pesticide, indicating a non-interactive, independent joint effect. For higher effect level mixtures (1 and 1.5 toxic units), metabolite changes associated with thiacloprid exposure began to dominate. The metabolomic effects of the two dissimilarly acting chemicals were distinct, confirming separate modes of action and both proved more toxic than anticipated from previous studies. In the mixtures, phenotypic effects were in accordance with IA estimates, while metabolite changes were dominated by Ni effects, even though chlorpyrifos contributed most to reproductive toxicity. This could be attributed to the greater systematic effect of Ni when compared to the more specifically acting chlorpyrifos
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Imidazoles
|2 NLM
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| 650 |
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|a Neonicotinoids
|2 NLM
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| 650 |
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|a Nitro Compounds
|2 NLM
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|a Pesticides
|2 NLM
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| 650 |
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|a Pyridines
|2 NLM
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| 650 |
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7 |
|a Soil Pollutants
|2 NLM
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| 650 |
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7 |
|a Thiazines
|2 NLM
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| 650 |
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7 |
|a imidacloprid
|2 NLM
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| 650 |
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7 |
|a 3BN7M937V8
|2 NLM
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| 650 |
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|a Nickel
|2 NLM
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| 650 |
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|a 7OV03QG267
|2 NLM
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| 650 |
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|a thiacloprid
|2 NLM
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| 650 |
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7 |
|a DSV3A944A4
|2 NLM
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| 650 |
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|a Chlorpyrifos
|2 NLM
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| 650 |
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|a JCS58I644W
|2 NLM
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| 700 |
1 |
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|a Spurgeon, D J
|e verfasserin
|4 aut
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1 |
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|a Svendsen, C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Griffin, J L
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Swain, Suresh C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sturzenbaum, Stephen R
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jones, O A H
|e verfasserin
|4 aut
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| 773 |
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8 |
|i Enthalten in
|t Ecotoxicology (London, England)
|d 1992
|g 21(2012), 5 vom: 21. Juli, Seite 1436-47
|w (DE-627)NLM098212214
|x 1573-3017
|7 nnns
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| 773 |
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|g volume:21
|g year:2012
|g number:5
|g day:21
|g month:07
|g pages:1436-47
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|u http://dx.doi.org/10.1007/s10646-012-0897-0
|3 Volltext
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