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231224s2012 xx |||||o 00| ||eng c |
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|a 10.1021/la204262w
|2 doi
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|a eng
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1 |
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|a Alexander, Shirin
|e verfasserin
|4 aut
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|a Growth and shrinkage of pluronic micelles by uptake and release of flurbiprofen
|b variation of pH
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|c 2012
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a Date Completed 18.09.2014
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|a Date Revised 11.12.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The micellization of Pluronic triblock copolymers (P103, P123, and L43) in the presence of flurbiprofen at different pH was studied by small-angle neutron scattering (SANS), pulsed-field gradient stimulated-echo nuclear magnetic resonance (PFGSE-NMR), and surface tension measurements. Addition of flurbiprofen to the Pluronic at low pH leads to an increase in the fraction of micellization, aggregation number, and the core radius of the micelles. However, changing the pH to above the pKa of flurbiprofen in an ethanol/water mixture (∼6.5) reduces the fraction of micellization and results in a weaker interaction between the drug and micelles due to the increased drug solubility in aqueous solution
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Micelles
|2 NLM
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|a Polymers
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|a pluronic block copolymer P123
|2 NLM
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|a 2E9U4Y94DB
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|a Flurbiprofen
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|a Poloxalene
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|a de Vos, Wiebe M
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|a Castle, Thomas C
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|a Cosgrove, Terence
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|a Prescott, Stuart W
|e verfasserin
|4 aut
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 28(2012), 16 vom: 24. Apr., Seite 6539-45
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|g year:2012
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|g month:04
|g pages:6539-45
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