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231224s2012 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2012.02.006
|2 doi
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|a pubmed24n0722.xml
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Qiao, Guilin
|e verfasserin
|4 aut
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| 245 |
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|a Program death-1 regulates peripheral T cell tolerance via an anergy-independent mechanism
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|c 2012
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 29.05.2012
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|a Date Revised 21.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2012 Elsevier Inc. All rights reserved.
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|a Program death-1 (PD-1) has been documented to negatively regulate immune responses. However, the cellular and molecular mechanisms for PD-1-mediated immune suppression have not been fully elucidated. In this study, we show that loss of PD-1 does not lead to defective induction of CD4(+) T cell anergy in vitro and in vivo. Rather, the absence of PD-1 inhibits the development of inducible CD4(+)Foxp3(+) regulatory T cells (iTregs) induced by TGF-β in vitro. In support of this finding, PD-1 deficiency impairs the generation of iTregs in vivo and leads to development of severe T cell-transfer-induced colitis. Mechanistically, defective iTreg generation in the absence of PD-1 was attributed to the heightened phosphorylation of Akt. Therefore, we first demonstrate that PD-1 controls peripheral T cell tolerance via an anergy-independent but iTreg-dependent mechanism
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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|a Homeodomain Proteins
|2 NLM
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|a Pdcd1 protein, mouse
|2 NLM
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|a Programmed Cell Death 1 Receptor
|2 NLM
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|a RAG-1 protein
|2 NLM
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|a 128559-51-3
|2 NLM
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| 700 |
1 |
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|a Yang, Lifen
|e verfasserin
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| 700 |
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|a Li, Zhenping
|e verfasserin
|4 aut
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| 700 |
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|a Ying, Haiyan
|e verfasserin
|4 aut
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| 700 |
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|a Hassen, Yassir
|e verfasserin
|4 aut
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| 700 |
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|a Yin, Fei
|e verfasserin
|4 aut
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| 700 |
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|a Zhang, Jian
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 143(2012), 2 vom: 07. Mai, Seite 128-33
|w (DE-627)NLM098196855
|x 1521-7035
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|g volume:143
|g year:2012
|g number:2
|g day:07
|g month:05
|g pages:128-33
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|u http://dx.doi.org/10.1016/j.clim.2012.02.006
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