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231224s2012 xx |||||o 00| ||eng c |
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|a 10.1021/la204741f
|2 doi
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|a pubmed24n0721.xml
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|a (NLM)22452574
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|a DE-627
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|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Dvores, Michelle P
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Formation of organic nanoparticles by electrospinning of volatile microemulsions
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|c 2012
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 17.08.2012
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|a Date Revised 01.12.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a This study presents a method for one-step formation of poly(ethylene oxide) nanofibers incorporating nanoparticles of a poorly water-soluble compound. Using the new method reported here, nanofiber-nanoparticle composites are fabricated in one step by electrospinning of an oil-in-water microemulsion, in which a model material, propylparaben, has been dissolved within the volatile dispersed phase in the presence of a high-molecular-weight polymer. The approach is based on nanoscale confinement to the dispersed phase of an oil-in-water microemulsion with a volatile oil phase, in which the poorly water-soluble materials are dissolved. Thus, when the thermodynamically stable oil-in-water microemulsion is combined with the rapid evaporation of solvent inherent in the electrospinning process, the droplets are converted into organic nanoparticles embedded within a polymeric nanofiber. In addition to possessing process simplicity, this method exhibits a very high percentage of nanoparticle loading with desirable active material properties. Specifically, the diameter of the nanofibers is in the range of 60-185 nm, and propylparaben exists within the nanofiber as nanocrystals of 30-120 nm. These dimensions suggest that the nanofiber-nanocrystal composites could serve as a delivery system for water-insoluble materials
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|a Journal Article
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|a Emulsions
|2 NLM
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|a Parabens
|2 NLM
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|a Water
|2 NLM
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|a 059QF0KO0R
|2 NLM
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|a Polyethylene Glycols
|2 NLM
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| 650 |
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|a 3WJQ0SDW1A
|2 NLM
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| 650 |
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|a propylparaben
|2 NLM
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| 650 |
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|a Z8IX2SC1OH
|2 NLM
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| 700 |
1 |
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|a Marom, Gad
|e verfasserin
|4 aut
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1 |
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|a Magdassi, Shlomo
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 28(2012), 17 vom: 01. Mai, Seite 6978-84
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:28
|g year:2012
|g number:17
|g day:01
|g month:05
|g pages:6978-84
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|u http://dx.doi.org/10.1021/la204741f
|3 Volltext
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