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231224s2012 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1021/la300093h
|2 doi
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|a pubmed24n0721.xml
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|a (DE-627)NLM216501318
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|a (NLM)22449117
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Partovi-Nia, Raheleh
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Study of amyloid β-peptide (Aβ12-28-Cys) interactions with Congo red and β-sheet breaker peptides using electrochemical impedance spectroscopy
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|c 2012
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 02.08.2012
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|a Date Revised 21.11.2013
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2012 American Chemical Society
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|a A surface-based approach is presented to study the interactions of Aβ12-28-Cys assembled on gold surfaces with Congo red (CR) and a β-sheet breaker (BSB) peptide. The various aspects of the peptide film have been examined using different electrochemical and surface analytical techniques. Cyclic voltammetry and electrochemical impedance spectroscopy (EIS) results using redox probes [Fe(CN)(6)](3-/4-) show that Aβ12-28-Cys on gold forms a stable and reproducible blocking film. EIS analysis shows that CR and BSB have different effects on the electrochemical properties of Aβ12-28-Cys films, presumably due to changes in the interactions between the film and CR and BSB. EIS results indicate that in the case of CR film resistance decreases significantly presumably due to better penetration of the solution-based redox probe into the film, whereas in the case of BSB, the film resistance increases. We interpret this difference to BSB being able to interact with the Aβ12-28-Cys on the surface and presumably forming a film that presents a higher resistance for electron transfer from the redox probe to the solution
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Amyloid beta-Peptides
|2 NLM
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|a Congo Red
|2 NLM
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| 650 |
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|a 3U05FHG59S
|2 NLM
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|a Gold
|2 NLM
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|a 7440-57-5
|2 NLM
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| 650 |
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|a Cysteine
|2 NLM
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| 650 |
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|a K848JZ4886
|2 NLM
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| 700 |
1 |
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|a Beheshti, Samaneh
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qin, Ziqiang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mandal, Himadri S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Long, Yi-Tao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Girault, Hubert H
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kraatz, Heinz-Bernhard
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1999
|g 28(2012), 15 vom: 17. Apr., Seite 6377-85
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:28
|g year:2012
|g number:15
|g day:17
|g month:04
|g pages:6377-85
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|u http://dx.doi.org/10.1021/la300093h
|3 Volltext
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