Synthesis and structure elucidation of five new conjugates of oleanolic acid derivatives and chalcones using 1D and 2D NMR spectroscopy

Synthesis and structure elucidation of five new conjugates of oleanolic acid derivatives and chalcones using 1D and 2D NMR spectroscopy

Copyright © 2012 John Wiley & Sons, Ltd.

Détails bibliographiques
Publié dans:Magnetic resonance in chemistry : MRC. - 1985. - 50(2012), 3 vom: 10. März, Seite 236-41
Auteur principal: Tang, Chu (Auteur)
Autres auteurs: Zhu, Linhui, Li, Jun, Qin, Rui, Liu, Chang, Chen, Yu, Yang, Guangzhong
Format: Article en ligne
Langue:English
Publié: 2012
Accès à la collection:Magnetic resonance in chemistry : MRC
Sujets:Journal Article Research Support, Non-U.S. Gov't Carbon Isotopes Chalcones Enzyme Inhibitors Glycoside Hydrolase Inhibitors Protons Oleanolic Acid 6SMK8R7TGJ Deuterium plus... AR09D82C7G alpha-Glucosidases EC 3.2.1.20
Description
Résumé:Copyright © 2012 John Wiley & Sons, Ltd.
Five new conjugates of oleanolic acid derivatives and chalcones have been designed and synthesized. The structure elucidation of these conjugates was accomplished by using extensive 1D ((1)H, (13)C) and 2D NMR spectroscopic studies (COSY, HSQC and HMBC); and α-glucosidase inhibitory activity is reported for these conjugates. Compound 2b (IC(50)  = 47.5 µm) displayed much stronger activity than oleanolic acid and acarbose
Description:Date Completed 09.10.2012
Date Revised 20.11.2014
published: Print-Electronic
Citation Status MEDLINE
ISSN:1097-458X
DOI:10.1002/mrc.2845