Halothane changes the domain structure of a binary lipid membrane

X-ray and neutron diffraction studies of a binary lipid membrane demonstrate that halothane at physiological concentrations produces a pronounced redistribution of lipids between domains of different lipid types identified by different lamellar d-spacings and isotope composition. In contrast, dichlo...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1985. - 28(2012), 10 vom: 13. März, Seite 4723-8
1. Verfasser: Weinrich, Michael (VerfasserIn)
Weitere Verfasser: Nanda, Hirsh, Worcester, David L, Majkrzak, Charles F, Maranville, Brian B, Bezrukov, Sergey M
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2012
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Anesthetics, Inhalation Membrane Lipids Phosphatidylcholines 1,2-dilauroylphosphatidylcholine 18285-71-7 1,2-Dipalmitoylphosphatidylcholine 2644-64-6 mehr... Halothane UQT9G45D1P
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520 |a X-ray and neutron diffraction studies of a binary lipid membrane demonstrate that halothane at physiological concentrations produces a pronounced redistribution of lipids between domains of different lipid types identified by different lamellar d-spacings and isotope composition. In contrast, dichlorohexafluorocyclobutane (F6), a halogenated nonanesthetic, does not produce such significant effects. These findings demonstrate a specific effect of inhalational anesthetics on mixing phase equilibria of a lipid mixture 
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