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01000caa a22002652 4500 |
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NLM215436733 |
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DE-627 |
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20250213162112.0 |
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tu |
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231224s2011 xx ||||| 00| ||chi c |
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|a pubmed25n0718.xml
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|a (DE-627)NLM215436733
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| 035 |
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|a (NLM)22336360
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Lin, Ping
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Detection of drug resistance due to the plasmid-mediated AmpC β-lactamase and genotype analysis in Klebsiella pneumoniae resulting in respiratory infections in children
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| 264 |
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1 |
|c 2011
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 08.04.2013
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| 500 |
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|a Date Revised 09.12.2020
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| 500 |
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a OBJECTIVE: To investigate the production and AmpC β-lactamase in Klebsiella (K.) pneumoniae resulting in respiratory infections in children, AmpC β-Lactamase genotypic resistance and typical resistance to common antibiotics so as to provide some references for selecting drugs in clinical treatment
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| 520 |
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|a METHOD: Microbiological identification was performed with the VITEK 60 System, extended spectrum β lactamases (ESBLs) were detected in accordance with the confirmatory test recommended by Clinical and Laboratory Standards Institute (CLSI) and drug sensitivity was determined with Kirby-Bauer method. Suspected positive strains of AmpC β-lactamase were screened with cefoxitin disk diffusion. The genotypes were analyzed by cefoxitin three-dimensional test, conjugation test and PCR sequencing
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| 520 |
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|a RESULT: Of the 135 isolates, 30.37% were ESBLs positive, 15.56% were AmpC β-lactamase positive. The positive rates for only AmpC β-Lactamase, both AmpC β-Lactamase and ESBLs, and only ESBLs were 8.15%, 7.41% and 22.96% respectively. The resistant genotypes for AmpC β-Lactamase-positive strains was that 19 strains were of DHA-1 type and 2 were of ACT-1 type. The resistance to drugs in β-lactamase-producing strains was obviously higher than that in non-β-lactamase-producing strains and more serious in those strains producing both AmpC β-Lactamase and ESBLs. Sensitivity of β-lactamase, non-β-lactamase and ESBLs producing strains to imipenem was as high as 100 percent
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| 520 |
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|a CONCLUSION: ESBLs- and AmpC-β-lactamase-producing strains of K. pneumoniae resulting in respiratory infections in children in Taizhou city, have a higher detection rate in Taizhou and AmpC-β-lactamase is mainly of DHA-1 genotype. AmpC-β-lactamase- and ESBLs-producing strains are highly resistant, so to restrict the use of β-lactam antibiotics is an important step to reduce the epidemic of β-lactamase-producing strains infection
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, U.S. Gov't, Non-P.H.S.
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| 650 |
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7 |
|a Bacterial Proteins
|2 NLM
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| 650 |
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7 |
|a AmpC beta-lactamases
|2 NLM
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| 650 |
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7 |
|a EC 3.5.2.6
|2 NLM
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| 650 |
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7 |
|a beta-Lactamases
|2 NLM
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| 650 |
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7 |
|a EC 3.5.2.6
|2 NLM
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhonghua er ke za zhi = Chinese journal of pediatrics
|d 1960
|g 49(2011), 12 vom: 15. Dez., Seite 921-5
|w (DE-627)NLM136249191
|x 0578-1310
|7 nnns
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| 773 |
1 |
8 |
|g volume:49
|g year:2011
|g number:12
|g day:15
|g month:12
|g pages:921-5
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_20
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| 912 |
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|a GBV_ILN_22
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_31
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| 912 |
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|a GBV_ILN_39
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| 912 |
|
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|a GBV_ILN_40
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| 912 |
|
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|a GBV_ILN_50
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| 912 |
|
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|a GBV_ILN_61
|
| 912 |
|
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|a GBV_ILN_65
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| 912 |
|
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|a GBV_ILN_69
|
| 912 |
|
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|a GBV_ILN_70
|
| 912 |
|
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|a GBV_ILN_72
|
| 912 |
|
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|a GBV_ILN_120
|
| 912 |
|
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|a GBV_ILN_130
|
| 912 |
|
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|a GBV_ILN_227
|
| 912 |
|
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|a GBV_ILN_244
|
| 912 |
|
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|a GBV_ILN_285
|
| 912 |
|
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|a GBV_ILN_294
|
| 912 |
|
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|a GBV_ILN_350
|
| 912 |
|
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|a GBV_ILN_665
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| 912 |
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|a GBV_ILN_813
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| 951 |
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|a AR
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| 952 |
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|d 49
|j 2011
|e 12
|b 15
|c 12
|h 921-5
|