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|a DE-627
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|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Yao, Sheng-hua
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Clinical application of tacrolimus with low-dose prednisone in 21 children with steroid-resistant nephrotic syndrome
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|c 2011
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|2 rdacarrier
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|a Date Completed 10.05.2012
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|a Date Revised 07.06.2016
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|a published: Print
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|a Citation Status MEDLINE
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|a OBJECTIVE: To analyze and evaluate the efficacy and safety of tacrolimus and low-dose steroids in the treatment of steroid-resistant nephrotic syndrome in children
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|a METHOD: Twenty-one children with steroid-resistant nephrotic syndrome enrolled from October 2008 to July 2010 into this retrospective longitudinal study received oral tacrolimus treatment, 0.1 to 0.15 mg/kg per day and once every 12 hours, and prednisone 0.2 to 0.75 mg/kg per day simultaneously. During the treatment, the plasma concentration of tacrolimus, urine volume, urine, serum creatinine and liver function were regularly monitored
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|a RESULT: After 1 to 3 months treatment, 14 cases showed complete remission and 7 cases had partial remission. Sixteen patients received renal biopsy, of whom 6 revealed minimal change nephropathy with complete remission in 3 cases, 3 cases had partial remission;4 cases revealed focal segmental glomerulosclerosis with 2 complete remission and 2 partial remission; other 5 children with IgM nephropathy and 1 mesangial proliferative glomerulonephritis achieved complete remission. Within treatment period, 6 patients presented transient adverse reactions, without altering the principle treatment strategy, but only taking the symptomatic treatment. During follow-up, 1 case was lost to follow-up and the remaining 20 cases were followed up from 2 months to 21 months. In 4 patients the disease relapsed within 1st-year follow-up, while at 2nd-year follow-up, 4 cases had (6 times) recurrence
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|a CONCLUSION: Tacrolimus showed a reliable effect in children with steroid-resistant nephrotic syndrome. Less adverse reactions were seen, and most of them could be tolerated. Nevertheless, the patients had a higher relapse rate after 1 to 2 years treatment. Therefore, the long-term effects of tacrolimus for steroid-resistant nephrotic syndrome remains to be further evaluated
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|a English Abstract
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 700 |
1 |
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|a Mao, Jian-hua
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|a Xia, Yong-hui
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| 700 |
1 |
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|a Wang, Da-yan
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| 700 |
1 |
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|a Chen, Yi-fang
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| 700 |
1 |
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|a Fang, Cheng-qing
|e verfasserin
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| 700 |
1 |
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|a Liu, Ai-min
|e verfasserin
|4 aut
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| 700 |
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|a Du, Li-zhong
|e verfasserin
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|i Enthalten in
|t Zhonghua er ke za zhi = Chinese journal of pediatrics
|d 1960
|g 49(2011), 11 vom: 15. Nov., Seite 825-8
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|g volume:49
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|d 49
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