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231224s2012 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2012.01.002
|2 doi
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|a pubmed24n0717.xml
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|a DE-627
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|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Grönwall, Caroline
|e verfasserin
|4 aut
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| 245 |
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|a IgM autoantibodies to distinct apoptosis-associated antigens correlate with protection from cardiovascular events and renal disease in patients with SLE
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|c 2012
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 12.04.2012
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|a Date Revised 31.03.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2012 Elsevier Inc. All rights reserved.
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|a Emerging evidence suggests that there are IgM-autoantibodies that may play protective roles in SLE. While IgM are often considered polyreactive, we postulate that there are distinct sets of IgM-autoantibodies of defined autoreactive specificities relevant to different features of SLE. We examined the relationships between levels of IgM natural autoantibodies (NAbs) to apoptosis-associated phosphorylcholine (PC) or malondialdehyde (MDA) antigens, with lupus-associated autoantibodies and features of disease, in 120 SLE patients. IgM anti-PC was significantly higher in patients with low disease activity and less organ damage determined by the SELENA-SLEDAI, the physician's evaluation and the SLICC damage score. Furthermore, IgM anti-PC was significantly higher in patients without cardiovascular events. In contrast, IgM anti-cardiolipin and IgM anti-dsDNA were significantly higher in patients without renal disease. These results support the hypothesis that some IgM autoantibodies are part of a natural immune repertoire that provide homeostatic functions and protection from certain clinical lupus features
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|a Journal Article
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|a Research Support, American Recovery and Reinvestment Act
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|a Research Support, N.I.H., Extramural
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Antibodies, Anti-Idiotypic
|2 NLM
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| 650 |
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|a Antigens
|2 NLM
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| 650 |
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|a Autoantibodies
|2 NLM
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|a anti-IgM
|2 NLM
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| 650 |
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|a Phosphorylcholine
|2 NLM
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| 650 |
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|a 107-73-3
|2 NLM
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| 650 |
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|a Malondialdehyde
|2 NLM
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| 650 |
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|a 4Y8F71G49Q
|2 NLM
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| 700 |
1 |
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|a Akhter, Ehtisham
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Oh, Cheongeun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Burlingame, Rufus W
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Petri, Michelle
|e verfasserin
|4 aut
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| 700 |
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|a Silverman, Gregg J
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 142(2012), 3 vom: 21. März, Seite 390-8
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|x 1521-7035
|7 nnns
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|g volume:142
|g year:2012
|g number:3
|g day:21
|g month:03
|g pages:390-8
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|u http://dx.doi.org/10.1016/j.clim.2012.01.002
|3 Volltext
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