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231224s2012 xx |||||o 00| ||eng c |
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|a 10.1021/la204717c
|2 doi
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|a pubmed24n0716.xml
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Hirano, Atsushi
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Adsorption and disruption of lipid bilayers by nanoscale protein aggregates
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|c 2012
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 13.06.2012
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|a Date Revised 28.02.2012
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2012 American Chemical Society
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|a Nanoparticles taken into biological systems can have biological impacts through their interactions with cell membranes, accompanied by protein adsorption onto the nanoparticle surfaces, forming a so-called protein corona. Our current research aims to demonstrate that nanoscale protein aggregates behave like such nanoparticles with regard to the interaction with lipid membranes. In this study, the adsorption and disruption of the lipid membranes by protein aggregates were investigated using amyloid fibrils and nanoscale thermal aggregates of lysozyme. Both types of protein aggregates had disruptive effects on the negatively charged liposomes, similar to polycationic nanoparticles. Interestingly, adsorption of liposomes on the amyloid fibrils preceding disruption occurred even if the net charge of the liposome was zero, suggesting the importance of hydrophobic interactions in addition to electrostatic interactions. The results of the present study provide new insights into the biological impacts of nanoparticles in vivo
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Amyloid
|2 NLM
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|a Lipid Bilayers
|2 NLM
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|a Liposomes
|2 NLM
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| 650 |
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|a Proteins
|2 NLM
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| 700 |
1 |
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|a Yoshikawa, Hiroki
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Matsushita, Shuhei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yamada, Yoichi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shiraki, Kentaro
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 28(2012), 8 vom: 28. Feb., Seite 3887-95
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
8 |
|g volume:28
|g year:2012
|g number:8
|g day:28
|g month:02
|g pages:3887-95
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| 856 |
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|u http://dx.doi.org/10.1021/la204717c
|3 Volltext
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