|
|
|
|
| LEADER |
01000caa a22002652 4500 |
| 001 |
NLM214529924 |
| 003 |
DE-627 |
| 005 |
20250213134331.0 |
| 007 |
tu |
| 008 |
231224s2011 xx ||||| 00| ||chi c |
| 028 |
5 |
2 |
|a pubmed25n0715.xml
|
| 035 |
|
|
|a (DE-627)NLM214529924
|
| 035 |
|
|
|a (NLM)22242225
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a chi
|
| 100 |
1 |
|
|a Li, Xiao-feng
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a N-acetylcysteine (NAC) inhibited pulmonary fibrosis in acute respiratory distress syndrome (ARDS)
|
| 264 |
|
1 |
|c 2011
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
|
| 338 |
|
|
|a Band
|b nc
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 14.06.2012
|
| 500 |
|
|
|a Date Revised 09.12.2020
|
| 500 |
|
|
|a published: Print
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a OBJECTIVE: To investigate the effect of NAC treatment on lipopolysaccharide (LPS) treated human embryonic lung fibroblasts (HELF), in regard to oxidant injury and changes in indexes related to pulmonary fibrosis in ARDS
|
| 520 |
|
|
|a METHODS: Four groups of cultured HELF were treated with: vehicle, LPS(1 pg/ml), NAC (1 mmol/L)+LPS (1 pg/ml) and dexamethasone (DEX, 1 pmol/L)+LPS (1 pg/ml) for 24 hours. The content of collagen and the γ-glutamylcysteinylglycine (GSH) in the cells were determined
|
| 520 |
|
|
|a RESULTS: As compared to the control group, the collagen content (pg/mg: 78.97+1.79 vs. 72.90+1.70)and GSH content (pg/mg: 23. 27 0. 92 vs. 26. 34+ 0. 83) in LPS group were significantly (P<0. 05) higher and lower, respectively; NAC and DEX both suppressed the effect of LPS on collagen content (72. 23 ± 1.35, 73.64 1.89 vs. 78.97 + 1.79); and GSH content (26.52 0.62, 25.85 ± 0.60 vs. 23.27+ 0.92)significantly (P < 0. 05 or P < 0. 01) in the treated cells. No significant difference was found between NAC+LPS and DEX+LPS group, either in the content of collagen or GSH
|
| 520 |
|
|
|a CONCLUSION: NAC can inhibit oxidant injury and pulmonary fibrosis in ARDS
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
7 |
|a Lipopolysaccharides
|2 NLM
|
| 650 |
|
7 |
|a gamma-glutamyl-glutathione
|2 NLM
|
| 650 |
|
7 |
|a 105644-04-0
|2 NLM
|
| 650 |
|
7 |
|a Collagen
|2 NLM
|
| 650 |
|
7 |
|a 9007-34-5
|2 NLM
|
| 650 |
|
7 |
|a Glutathione
|2 NLM
|
| 650 |
|
7 |
|a GAN16C9B8O
|2 NLM
|
| 650 |
|
7 |
|a Acetylcysteine
|2 NLM
|
| 650 |
|
7 |
|a WYQ7N0BPYC
|2 NLM
|
| 700 |
1 |
|
|a Ouyang, Bin
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Wu, Jian-feng
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Chen, Juan
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Guan, Xiang-dong
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 23(2011), 10 vom: 18. Okt., Seite 599-601
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
|
| 773 |
1 |
8 |
|g volume:23
|g year:2011
|g number:10
|g day:18
|g month:10
|g pages:599-601
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 23
|j 2011
|e 10
|b 18
|c 10
|h 599-601
|