Phenotype and function of dendritic cells of patients with systemic lupus erythematosus
Copyright © 2011 Elsevier Inc. All rights reserved.
| Veröffentlicht in: | Clinical immunology (Orlando, Fla.). - 1999. - 143(2012), 1 vom: 12. Apr., Seite 45-50 |
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| 1. Verfasser: | |
| Weitere Verfasser: | , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2012
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| Zugriff auf das übergeordnete Werk: | Clinical immunology (Orlando, Fla.) |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't B7-1 Antigen B7-2 Antigen CD80-CAP Interleukin-6 Lipopolysaccharides Oligopeptides Tumor Necrosis Factor-alpha Interleukin-10 mehr... |
| Zusammenfassung: | Copyright © 2011 Elsevier Inc. All rights reserved. Dendritic cells (DC) regulate the activation and differentiation of T cells. They are activated by signals of inflammation and tissue damage, and thus could play a role in the amplification and perpetuation of autoimmune diseases such as systemic lupus erythematosus (SLE). Here we analyzed the phenotype of circulating DC from patients with SLE and studied their differentiation from monocytes. Peripheral blood DC exhibited increased levels of activation in patients with SLE. Although their in vitro differentiation process occurred normally, their responses to activation stimuli (LPS, TNF-α plus PGE(2), anti-CD40) were abnormal when compared to DC differentiated from healthy monocytes. When incubated in the presence of IL-10, DC from patients with SLE were able to induce tolerance to allogeneic antigens in a normal manner. Our results suggest that DC from patients with SLE are abnormal, in part due to the effect of abundant pro-inflammatory signals, but also because of intrinsic cellular defects that alter their responses to activation stimuli |
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| Beschreibung: | Date Completed 11.05.2012 Date Revised 16.11.2017 published: Print-Electronic CommentIn: Clin Immunol. 2012 Apr;143(1):4-5. doi: 10.1016/j.clim.2012.01.006. - PMID 22326124 Citation Status MEDLINE |
| ISSN: | 1521-7035 |
| DOI: | 10.1016/j.clim.2011.12.004 |