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231224s2012 xx |||||o 00| ||eng c |
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|a 10.1007/s10646-011-0844-5
|2 doi
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|a pubmed25n0714.xml
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|a (DE-627)NLM214394298
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|a (NLM)22227859
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Rattner, Barnett A
|e verfasserin
|4 aut
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|a Assessment of toxicity and potential risk of the anticoagulant rodenticide diphacinone using Eastern screech-owls (Megascops asio)
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|c 2012
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 10.07.2012
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|a Date Revised 21.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a In the United States, new regulatory restrictions have been placed on the use of some second-generation anticoagulant rodenticides. This action may be offset by expanded use of first-generation compounds (e.g., diphacinone; DPN). Single-day acute oral exposure of adult Eastern screech-owls (Megascops asio) to DPN evoked overt signs of intoxication, coagulopathy, histopathological lesions (e.g., hemorrhage, hepatocellular vacuolation), and/or lethality at doses as low as 130 mg/kg body weight, although there was no dose-response relation. However, this single-day exposure protocol does not mimic the multiple-day field exposures required to cause mortality in rodent pest species and non-target birds and mammals. In 7-day feeding trials, similar toxic effects were observed in owls fed diets containing 2.15, 9.55 or 22.6 ppm DPN, but at a small fraction (<5%) of the acute oral dose. In the dietary trial, the average lowest-observed-adverse-effect-level for prolonged clotting time was 1.68 mg DPN/kg owl/week (0.24 mg/kg owl/day; 0.049 mg/owl/day) and the lowest lethal dose was 5.75 mg DPN/kg owl/week (0.82 mg/kg owl/day). In this feeding trial, DPN concentration in liver ranged from 0.473 to 2.21 μg/g wet weight, and was directly related to the daily and cumulative dose consumed by each owl. A probabilistic risk assessment indicated that daily exposure to as little as 3-5 g of liver from DPN-poisoned rodents for 7 days could result in prolonged clotting time in the endangered Hawaiian short-eared owl (Asio flammeus sandwichensis) and Hawaiian hawk (Buteo solitarius), and daily exposure to greater quantities (9-13 g of liver) could result in low-level mortality. These findings can assist natural resource managers in weighing the costs and benefits of anticoagulant rodenticide use in pest control and eradication programs
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Research Support, U.S. Gov't, Non-P.H.S.
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| 650 |
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|a Anticoagulants
|2 NLM
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| 650 |
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|a Rodenticides
|2 NLM
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| 650 |
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|a diphenadione
|2 NLM
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| 650 |
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|a 54CA01C6JX
|2 NLM
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| 650 |
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|a Phenindione
|2 NLM
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| 650 |
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|a 5M7Y6274ZE
|2 NLM
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| 700 |
1 |
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|a Horak, Katherine E
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lazarus, Rebecca S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Eisenreich, Karen M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Meteyer, Carol U
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Volker, Steven F
|e verfasserin
|4 aut
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| 700 |
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|a Campton, Christopher M
|e verfasserin
|4 aut
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| 700 |
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|a Eisemann, John D
|e verfasserin
|4 aut
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| 700 |
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|a Johnston, John J
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Ecotoxicology (London, England)
|d 1998
|g 21(2012), 3 vom: 14. Apr., Seite 832-46
|w (DE-627)NLM098212214
|x 1573-3017
|7 nnns
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| 773 |
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|g volume:21
|g year:2012
|g number:3
|g day:14
|g month:04
|g pages:832-46
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|u http://dx.doi.org/10.1007/s10646-011-0844-5
|3 Volltext
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